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Regulating the regulator: NF-kappaB signaling in heart.

Publication ,  Journal Article
Hall, G; Hasday, JD; Rogers, TB
Published in: J Mol Cell Cardiol
October 2006

The Nuclear Factor-kappaB (NF-kappaB) signaling pathway has been linked to several pathologic processes in the myocardium including cardiomyocyte proinflammatory cytokine release, ischemia/reperfusion injury, hypertrophy and apoptosis. However, very little is known about the intracellular mechanisms that govern NF-kappaB activity in the myocardial cells. Recent advances in our understanding of the regulation of NF-kappaB signaling in non-myocyte systems suggest that the activity of the NF-kappaB pathway is tightly regulated by a diversity of stress-activated signaling intermediates through direct post-translational modification of various components of the NF-kappaB pathway. In this review, we will focus on these recent revelations and their implications not only in cardiac pathologies, but in the development of new therapeutic strategies to manage heart disease.

Duke Scholars

Published In

J Mol Cell Cardiol

DOI

ISSN

0022-2828

Publication Date

October 2006

Volume

41

Issue

4

Start / End Page

580 / 591

Location

England

Related Subject Headings

  • Transcription, Genetic
  • Signal Transduction
  • Protein Processing, Post-Translational
  • Phosphorylation
  • NF-kappa B
  • Myocardium
  • Models, Biological
  • I-kappa B Proteins
  • Humans
  • Heart Diseases
 

Citation

APA
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MLA
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Hall, G., Hasday, J. D., & Rogers, T. B. (2006). Regulating the regulator: NF-kappaB signaling in heart. J Mol Cell Cardiol, 41(4), 580–591. https://doi.org/10.1016/j.yjmcc.2006.07.006
Hall, Gentzon, Jeffery D. Hasday, and Terry B. Rogers. “Regulating the regulator: NF-kappaB signaling in heart.J Mol Cell Cardiol 41, no. 4 (October 2006): 580–91. https://doi.org/10.1016/j.yjmcc.2006.07.006.
Hall G, Hasday JD, Rogers TB. Regulating the regulator: NF-kappaB signaling in heart. J Mol Cell Cardiol. 2006 Oct;41(4):580–91.
Hall, Gentzon, et al. “Regulating the regulator: NF-kappaB signaling in heart.J Mol Cell Cardiol, vol. 41, no. 4, Oct. 2006, pp. 580–91. Pubmed, doi:10.1016/j.yjmcc.2006.07.006.
Hall G, Hasday JD, Rogers TB. Regulating the regulator: NF-kappaB signaling in heart. J Mol Cell Cardiol. 2006 Oct;41(4):580–591.
Journal cover image

Published In

J Mol Cell Cardiol

DOI

ISSN

0022-2828

Publication Date

October 2006

Volume

41

Issue

4

Start / End Page

580 / 591

Location

England

Related Subject Headings

  • Transcription, Genetic
  • Signal Transduction
  • Protein Processing, Post-Translational
  • Phosphorylation
  • NF-kappa B
  • Myocardium
  • Models, Biological
  • I-kappa B Proteins
  • Humans
  • Heart Diseases