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Biocompatibility studies of functionalized regioregular poly(3-hexylthiophene) layers for sensing applications.

Publication ,  Journal Article
Scarpa, G; Idzko, A-L; Götz, S; Thalhammer, S
Published in: Macromol Biosci
April 8, 2010

There is a significant medical and biological need for cheap disposable analytical sensing devices, which can be used in clinical settings or medical research. Organic electronics based on polymeric materials, being suitable for large-area, low-cost, flexible, and maybe even disposable electronics, could satisfy this need in a very elegant way. Unfortunately, the ensurance of biocompatibility and biofunctionalization of conducting and semiconducting polymers is still often lacking. In the present study, we concentrate on one of the most promising polymeric materials, regioregular poly(3-hexylthiophene) (P3HT), being both a reasonably conducting and optically active polymer. To overcome biocompatibility problems, protein-based coatings and oxygen-plasma treatments are performed to enable growth of adherent living cells on those modified surfaces. For our studies, the polymer material is spun or casted onto glass substrates under an inert nitrogen atmosphere. The toxic solvents are removed by thermal treatment with subsequent application of the coating or functionalizing materials. Cell-growth studies and adhesion experiments on the modified P3HT thin-film layers are carried out with mouse fibroblasts. This work demonstrates the biocompatibility and biofunctionalization of an active semiconducting organic polymer, hence opening new possibilities in the realization of biomedical test systems based on organic biosensors in life sciences.

Duke Scholars

Published In

Macromol Biosci

DOI

EISSN

1616-5195

Publication Date

April 8, 2010

Volume

10

Issue

4

Start / End Page

378 / 383

Location

Germany

Related Subject Headings

  • Wettability
  • Thiophenes
  • Semiconductors
  • Polymers
  • Polylysine
  • Oxygen
  • Oxidation-Reduction
  • Microscopy, Atomic Force
  • Mice
  • Materials Testing
 

Citation

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Scarpa, G., Idzko, A.-L., Götz, S., & Thalhammer, S. (2010). Biocompatibility studies of functionalized regioregular poly(3-hexylthiophene) layers for sensing applications. Macromol Biosci, 10(4), 378–383. https://doi.org/10.1002/mabi.200900412
Scarpa, Giuseppe, Anna-Lena Idzko, Stefan Götz, and Stefan Thalhammer. “Biocompatibility studies of functionalized regioregular poly(3-hexylthiophene) layers for sensing applications.Macromol Biosci 10, no. 4 (April 8, 2010): 378–83. https://doi.org/10.1002/mabi.200900412.
Scarpa G, Idzko A-L, Götz S, Thalhammer S. Biocompatibility studies of functionalized regioregular poly(3-hexylthiophene) layers for sensing applications. Macromol Biosci. 2010 Apr 8;10(4):378–83.
Scarpa, Giuseppe, et al. “Biocompatibility studies of functionalized regioregular poly(3-hexylthiophene) layers for sensing applications.Macromol Biosci, vol. 10, no. 4, Apr. 2010, pp. 378–83. Pubmed, doi:10.1002/mabi.200900412.
Scarpa G, Idzko A-L, Götz S, Thalhammer S. Biocompatibility studies of functionalized regioregular poly(3-hexylthiophene) layers for sensing applications. Macromol Biosci. 2010 Apr 8;10(4):378–383.
Journal cover image

Published In

Macromol Biosci

DOI

EISSN

1616-5195

Publication Date

April 8, 2010

Volume

10

Issue

4

Start / End Page

378 / 383

Location

Germany

Related Subject Headings

  • Wettability
  • Thiophenes
  • Semiconductors
  • Polymers
  • Polylysine
  • Oxygen
  • Oxidation-Reduction
  • Microscopy, Atomic Force
  • Mice
  • Materials Testing