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Quantitative assessment of autism symptom-related traits in probands and parents: Broader Phenotype Autism Symptom Scale.

Publication ,  Journal Article
Dawson, G; Estes, A; Munson, J; Schellenberg, G; Bernier, R; Abbott, R
Published in: J Autism Dev Disord
March 2007

Autism susceptibility genes likely have effects on continuously distributed autism-related traits, yet few measures of such traits exist. The Broader Phenotype Autism Symptom Scale (BPASS), developed for use with affected children and family members, measures social motivation, social expressiveness, conversational skills, and flexibility. Based on 201 multiplex families, psychometric data on the BPASS are reported. Adequate inter-rater reliability and internal consistency were found. Parents had lower BPASS scores than affected children, after controlling for IQ. Parents and affected children showed overlapping distributions suggesting the BPASS captured variability in traits across groups. BPASS scores were not correlated with ethnicity or parent education; however, some domains were correlated with IQ. The BPASS holds promise as a quantitative phenotypic assessment for genetic studies.

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Published In

J Autism Dev Disord

DOI

ISSN

0162-3257

Publication Date

March 2007

Volume

37

Issue

3

Start / End Page

523 / 536

Location

United States

Related Subject Headings

  • Verbal Behavior
  • Social Behavior
  • Social Adjustment
  • Siblings
  • Reproducibility of Results
  • Quantitative Trait, Heritable
  • Phenotype
  • Parents
  • Motivation
  • Male
 

Citation

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Dawson, G., Estes, A., Munson, J., Schellenberg, G., Bernier, R., & Abbott, R. (2007). Quantitative assessment of autism symptom-related traits in probands and parents: Broader Phenotype Autism Symptom Scale. J Autism Dev Disord, 37(3), 523–536. https://doi.org/10.1007/s10803-006-0182-2
Dawson, Geraldine, Annette Estes, Jeffrey Munson, Gerard Schellenberg, Raphael Bernier, and Robert Abbott. “Quantitative assessment of autism symptom-related traits in probands and parents: Broader Phenotype Autism Symptom Scale.J Autism Dev Disord 37, no. 3 (March 2007): 523–36. https://doi.org/10.1007/s10803-006-0182-2.
Dawson G, Estes A, Munson J, Schellenberg G, Bernier R, Abbott R. Quantitative assessment of autism symptom-related traits in probands and parents: Broader Phenotype Autism Symptom Scale. J Autism Dev Disord. 2007 Mar;37(3):523–36.
Dawson, Geraldine, et al. “Quantitative assessment of autism symptom-related traits in probands and parents: Broader Phenotype Autism Symptom Scale.J Autism Dev Disord, vol. 37, no. 3, Mar. 2007, pp. 523–36. Pubmed, doi:10.1007/s10803-006-0182-2.
Dawson G, Estes A, Munson J, Schellenberg G, Bernier R, Abbott R. Quantitative assessment of autism symptom-related traits in probands and parents: Broader Phenotype Autism Symptom Scale. J Autism Dev Disord. 2007 Mar;37(3):523–536.
Journal cover image

Published In

J Autism Dev Disord

DOI

ISSN

0162-3257

Publication Date

March 2007

Volume

37

Issue

3

Start / End Page

523 / 536

Location

United States

Related Subject Headings

  • Verbal Behavior
  • Social Behavior
  • Social Adjustment
  • Siblings
  • Reproducibility of Results
  • Quantitative Trait, Heritable
  • Phenotype
  • Parents
  • Motivation
  • Male