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Clinical applications for biomarkers of acute and chronic graft-versus-host disease.

Publication ,  Journal Article
Levine, JE; Paczesny, S; Sarantopoulos, S
Published in: Biol Blood Marrow Transplant
January 2012

Acute and chronic graft-versus-host disease (aGVHD, cGVHD) are serious complications of allogeneic hematopoietic cell transplantation. The complex pathophysiology of these disease processes is associated with immune system activation, the release of cytokines and chemokines, and alterations in cell populations. The blood levels of specific protein and cellular levels in patients with GVHD have correlated with the development, diagnosis, and prognosis of GVHD. Here, we review the most promising biomarkers for aGVHD and cGVHD with clinical relevance. The utility of GVHD biomarkers in clinical care of allogeneic hematopoietic cell transplantation recipients needs to be proven through clinical trials, and potential approaches to trial design are discussed.

Duke Scholars

Published In

Biol Blood Marrow Transplant

DOI

EISSN

1523-6536

Publication Date

January 2012

Volume

18

Issue

1 Suppl

Start / End Page

S116 / S124

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • Prognosis
  • Male
  • Immunology
  • Humans
  • Hematopoietic Stem Cell Transplantation
  • Graft vs Host Disease
  • Female
  • Clinical Trials as Topic
  • Chronic Disease
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Levine, J. E., Paczesny, S., & Sarantopoulos, S. (2012). Clinical applications for biomarkers of acute and chronic graft-versus-host disease. Biol Blood Marrow Transplant, 18(1 Suppl), S116–S124. https://doi.org/10.1016/j.bbmt.2011.10.019
Levine, John E., Sophie Paczesny, and Stefanie Sarantopoulos. “Clinical applications for biomarkers of acute and chronic graft-versus-host disease.Biol Blood Marrow Transplant 18, no. 1 Suppl (January 2012): S116–24. https://doi.org/10.1016/j.bbmt.2011.10.019.
Levine JE, Paczesny S, Sarantopoulos S. Clinical applications for biomarkers of acute and chronic graft-versus-host disease. Biol Blood Marrow Transplant. 2012 Jan;18(1 Suppl):S116–24.
Levine, John E., et al. “Clinical applications for biomarkers of acute and chronic graft-versus-host disease.Biol Blood Marrow Transplant, vol. 18, no. 1 Suppl, Jan. 2012, pp. S116–24. Pubmed, doi:10.1016/j.bbmt.2011.10.019.
Levine JE, Paczesny S, Sarantopoulos S. Clinical applications for biomarkers of acute and chronic graft-versus-host disease. Biol Blood Marrow Transplant. 2012 Jan;18(1 Suppl):S116–S124.
Journal cover image

Published In

Biol Blood Marrow Transplant

DOI

EISSN

1523-6536

Publication Date

January 2012

Volume

18

Issue

1 Suppl

Start / End Page

S116 / S124

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • Prognosis
  • Male
  • Immunology
  • Humans
  • Hematopoietic Stem Cell Transplantation
  • Graft vs Host Disease
  • Female
  • Clinical Trials as Topic
  • Chronic Disease