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Steroid 5-alpha-reductase type 2 (SRD5A2) V89L and A49T polymorphisms and sporadic prostate cancer risk: a meta-analysis.

Publication ,  Journal Article
Li, Q; Zhu, Y; He, J; Wang, M; Zhu, M; Shi, T; Qiu, L; Ye, D; Wei, Q
Published in: Mol Biol Rep
May 2013

Steroid 5-α-reductase type 2 (SRD5A2) V89L and A49T polymorphisms are thought to play a crucial role in the androgen synthesis and metabolic pathway, but their associations with prostate cancer risk remain controversial. To provide a more precise estimation of the associations between V89L and A49T polymorphisms and prostate cancer risk, we performed a meta-analysis using all published case-control studies of prostate cancer since January 1995. We used odds ratio (OR) and its 95% confidence interval (CI) to assess the strength of the association under various genetic models in both overall and stratified analyses. We also calculated the false-positive report probability, the power of the current study, and the observed P value for significant findings. This analysis included 45 eligible studies of a total of 15,562 cases and 15,385 controls, in which no significant associations were found for the V89L polymorphisms under all genetic models. However, small excess prostate cancer risk was associated with the 49T allele in mixed populations compared with the 49A allele (OR = 1.24, 95% CI = 1.02-1.50), and similar results were observed in Caucasians (OR = 1.24, 95% CI = 1.01-1.53). The sensitivity analysis further strengthened the validity of these findings without publication bias. Although there was no overall association between V89L and prostate cancer risk, A49T might play a role in the etiology of prostate cancer among Caucasians. Additional large and well-designed studies are warranted to validate these findings.

Duke Scholars

Published In

Mol Biol Rep

DOI

EISSN

1573-4978

Publication Date

May 2013

Volume

40

Issue

5

Start / End Page

3597 / 3608

Location

Netherlands

Related Subject Headings

  • Risk
  • Publication Bias
  • Prostatic Neoplasms
  • Polymorphism, Single Nucleotide
  • Odds Ratio
  • Male
  • Humans
  • Genotype
  • Genetic Predisposition to Disease
  • Biochemistry & Molecular Biology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Li, Q., Zhu, Y., He, J., Wang, M., Zhu, M., Shi, T., … Wei, Q. (2013). Steroid 5-alpha-reductase type 2 (SRD5A2) V89L and A49T polymorphisms and sporadic prostate cancer risk: a meta-analysis. Mol Biol Rep, 40(5), 3597–3608. https://doi.org/10.1007/s11033-012-2434-x
Li, Qiaoxin, Yao Zhu, Jing He, Mengyun Wang, Meiling Zhu, Tingyan Shi, Lixin Qiu, Dingwei Ye, and Qingyi Wei. “Steroid 5-alpha-reductase type 2 (SRD5A2) V89L and A49T polymorphisms and sporadic prostate cancer risk: a meta-analysis.Mol Biol Rep 40, no. 5 (May 2013): 3597–3608. https://doi.org/10.1007/s11033-012-2434-x.
Li Q, Zhu Y, He J, Wang M, Zhu M, Shi T, et al. Steroid 5-alpha-reductase type 2 (SRD5A2) V89L and A49T polymorphisms and sporadic prostate cancer risk: a meta-analysis. Mol Biol Rep. 2013 May;40(5):3597–608.
Li, Qiaoxin, et al. “Steroid 5-alpha-reductase type 2 (SRD5A2) V89L and A49T polymorphisms and sporadic prostate cancer risk: a meta-analysis.Mol Biol Rep, vol. 40, no. 5, May 2013, pp. 3597–608. Pubmed, doi:10.1007/s11033-012-2434-x.
Li Q, Zhu Y, He J, Wang M, Zhu M, Shi T, Qiu L, Ye D, Wei Q. Steroid 5-alpha-reductase type 2 (SRD5A2) V89L and A49T polymorphisms and sporadic prostate cancer risk: a meta-analysis. Mol Biol Rep. 2013 May;40(5):3597–3608.
Journal cover image

Published In

Mol Biol Rep

DOI

EISSN

1573-4978

Publication Date

May 2013

Volume

40

Issue

5

Start / End Page

3597 / 3608

Location

Netherlands

Related Subject Headings

  • Risk
  • Publication Bias
  • Prostatic Neoplasms
  • Polymorphism, Single Nucleotide
  • Odds Ratio
  • Male
  • Humans
  • Genotype
  • Genetic Predisposition to Disease
  • Biochemistry & Molecular Biology