Skip to main content

[Human chromosome 8p11 (CHRNB3-CHRNA6) region gene polymorphisms and susceptibility to lung cancer in Chinese Han population].

Publication ,  Journal Article
Zhang, X-B; Zhao, Z-H; Chen, H-Y; Wang, J-C; Qian, J; Yang, Y-J; Wei, Q-Y; Huang, J; Lu, D-R
Published in: Yi Chuan
August 2011

To investigate the association between chromosome 8p11 (CHRNB3-CHRNA6) polymorphisms and lung cancer susceptibility in Chinese Han population, we genotyped 6 tag SNPs variants of this region among 784 patients with lung cancer and 782 age- and sex-matched cancer-free control participants to screen for any risk-associated SNPs. The results revealed that rs16891561 TT genotype had a protective effect against lung cancer in people over 60 years old (adjusted OR=0.42, 95% CI=0.20-0.88; P=0.022), female groups (adjusted OR=0.34, 95% CI=0.13-0.87; P=0.025), and non-smoking people (adjusted OR=0.32, 95% CI=0.13-079; P=0.013). Additionally, rs4236926 TT genotype had a protective effect against lung cancer in people over 60 years old (adjusted OR=0.48, 95% CI=0.23-0.99; P=0.048) and non-smoking people (adjusted OR=0.32, 95% CI=0.13-0.80; P=0.014). According to pathological type of lung cancer, these two SNPs were associated with adenocarcinomas susceptibility. As to cumulative effect of rs4236926 and rs16891561, in non-smokers strata, lung cancer risk was significantly reduced in those who had 3-4 mutant alleles (adjusted OR=0.29, 95% CI=0.11-0.71; P=0.007). Furthermore, people containing 3-4 mutant alleles had lower level of smoking doses (mean pack-year=13.2) compared with others. In conclusion, 8p11 (CHRNB3-CHRNA6) polymorphisms are related to smoking behavior and lung cancer susceptibility in Chinese Han population.

Duke Scholars

Published In

Yi Chuan

DOI

ISSN

0253-9772

Publication Date

August 2011

Volume

33

Issue

8

Start / End Page

886 / 894

Location

China

Related Subject Headings

  • Smoking
  • Risk Factors
  • Receptors, Nicotinic
  • Polymorphism, Single Nucleotide
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Humans
  • Genotype
  • Genetic Predisposition to Disease
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zhang, X.-B., Zhao, Z.-H., Chen, H.-Y., Wang, J.-C., Qian, J., Yang, Y.-J., … Lu, D.-R. (2011). [Human chromosome 8p11 (CHRNB3-CHRNA6) region gene polymorphisms and susceptibility to lung cancer in Chinese Han population]. Yi Chuan, 33(8), 886–894. https://doi.org/10.3724/sp.j.1005.2011.00886
Zhang, Xiao-Bo, Zhen-Hong Zhao, Hong-Yan Chen, Jiu-Cun Wang, Ji Qian, Ya-Jun Yang, Qing-Yi Wei, Jian Huang, and Da-Ru Lu. “[Human chromosome 8p11 (CHRNB3-CHRNA6) region gene polymorphisms and susceptibility to lung cancer in Chinese Han population].Yi Chuan 33, no. 8 (August 2011): 886–94. https://doi.org/10.3724/sp.j.1005.2011.00886.
Zhang X-B, Zhao Z-H, Chen H-Y, Wang J-C, Qian J, Yang Y-J, et al. [Human chromosome 8p11 (CHRNB3-CHRNA6) region gene polymorphisms and susceptibility to lung cancer in Chinese Han population]. Yi Chuan. 2011 Aug;33(8):886–94.
Zhang, Xiao-Bo, et al. “[Human chromosome 8p11 (CHRNB3-CHRNA6) region gene polymorphisms and susceptibility to lung cancer in Chinese Han population].Yi Chuan, vol. 33, no. 8, Aug. 2011, pp. 886–94. Pubmed, doi:10.3724/sp.j.1005.2011.00886.
Zhang X-B, Zhao Z-H, Chen H-Y, Wang J-C, Qian J, Yang Y-J, Wei Q-Y, Huang J, Lu D-R. [Human chromosome 8p11 (CHRNB3-CHRNA6) region gene polymorphisms and susceptibility to lung cancer in Chinese Han population]. Yi Chuan. 2011 Aug;33(8):886–894.

Published In

Yi Chuan

DOI

ISSN

0253-9772

Publication Date

August 2011

Volume

33

Issue

8

Start / End Page

886 / 894

Location

China

Related Subject Headings

  • Smoking
  • Risk Factors
  • Receptors, Nicotinic
  • Polymorphism, Single Nucleotide
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Humans
  • Genotype
  • Genetic Predisposition to Disease