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An examination of male and female odds ratios by BMI, cigarette smoking, and alcohol consumption for cancers of the oral cavity, pharynx, and larynx in pooled data from 15 case-control studies.

Publication ,  Journal Article
Lubin, JH; Muscat, J; Gaudet, MM; Olshan, AF; Curado, MP; Dal Maso, L; Wünsch-Filho, V; Sturgis, EM; Szeszenia-Dabrowska, N; Castellsague, X ...
Published in: Cancer Causes Control
September 2011

BACKGROUND: Greater tobacco smoking and alcohol consumption and lower body mass index (BMI) increase odds ratios (OR) for oral cavity, oropharyngeal, hypopharyngeal, and laryngeal cancers; however, there are no comprehensive sex-specific comparisons of ORs for these factors. METHODS: We analyzed 2,441 oral cavity (925 women and 1,516 men), 2,297 oropharynx (564 women and 1,733 men), 508 hypopharynx (96 women and 412 men), and 1,740 larynx (237 women and 1,503 men) cases from the INHANCE consortium of 15 head and neck cancer case-control studies. Controls numbered from 7,604 to 13,829 subjects, depending on analysis. Analyses fitted linear-exponential excess ORs models. RESULTS: ORs were increased in underweight (< 18.5 BMI) relative to normal weight (18.5-24.9) and reduced in overweight and obese categories (≥ 25 BMI) for all sites and were homogeneous by sex. ORs by smoking and drinking in women compared with men were significantly greater for oropharyngeal cancer (p < 0.01 for both factors), suggestive for hypopharyngeal cancer (p = 0.05 and p = 0.06, respectively), but homogeneous for oral cavity (p = 0.56 and p = 0.64) and laryngeal (p = 0.18 and p = 0.72) cancers. CONCLUSIONS: The extent that OR modifications of smoking and drinking by sex for oropharyngeal and, possibly, hypopharyngeal cancers represent true associations, or derive from unmeasured confounders or unobserved sex-related disease subtypes (e.g., human papillomavirus-positive oropharyngeal cancer) remains to be clarified.

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Published In

Cancer Causes Control

DOI

EISSN

1573-7225

Publication Date

September 2011

Volume

22

Issue

9

Start / End Page

1217 / 1231

Location

Netherlands

Related Subject Headings

  • Smoking
  • Sex Factors
  • Risk Factors
  • Oropharyngeal Neoplasms
  • Odds Ratio
  • Mouth Neoplasms
  • Male
  • Laryngeal Neoplasms
  • Hypopharyngeal Neoplasms
  • Humans
 

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Lubin, J. H., Muscat, J., Gaudet, M. M., Olshan, A. F., Curado, M. P., Dal Maso, L., … Hashibe, M. (2011). An examination of male and female odds ratios by BMI, cigarette smoking, and alcohol consumption for cancers of the oral cavity, pharynx, and larynx in pooled data from 15 case-control studies. Cancer Causes Control, 22(9), 1217–1231. https://doi.org/10.1007/s10552-011-9792-x
Lubin, Jay H., Joshua Muscat, Mia M. Gaudet, Andrew F. Olshan, Maria Paula Curado, Luigino Dal Maso, Victor Wünsch-Filho, et al. “An examination of male and female odds ratios by BMI, cigarette smoking, and alcohol consumption for cancers of the oral cavity, pharynx, and larynx in pooled data from 15 case-control studies.Cancer Causes Control 22, no. 9 (September 2011): 1217–31. https://doi.org/10.1007/s10552-011-9792-x.
Lubin, Jay H., et al. “An examination of male and female odds ratios by BMI, cigarette smoking, and alcohol consumption for cancers of the oral cavity, pharynx, and larynx in pooled data from 15 case-control studies.Cancer Causes Control, vol. 22, no. 9, Sept. 2011, pp. 1217–31. Pubmed, doi:10.1007/s10552-011-9792-x.
Lubin JH, Muscat J, Gaudet MM, Olshan AF, Curado MP, Dal Maso L, Wünsch-Filho V, Sturgis EM, Szeszenia-Dabrowska N, Castellsague X, Zhang Z-F, Smith E, Fernandez L, Matos E, Franceschi S, Fabianova E, Rudnai P, Purdue MP, Mates D, Wei Q, Herrero R, Kelsey K, Morgenstern H, Shangina O, Koifman S, Lissowska J, Levi F, Daudt AW, Neto JE, Chen C, Lazarus P, Winn DM, Schwartz SM, Boffetta P, Brennan P, Menezes A, La Vecchia C, McClean M, Talamini R, Rajkumar T, Hayes RB, Hashibe M. An examination of male and female odds ratios by BMI, cigarette smoking, and alcohol consumption for cancers of the oral cavity, pharynx, and larynx in pooled data from 15 case-control studies. Cancer Causes Control. 2011 Sep;22(9):1217–1231.
Journal cover image

Published In

Cancer Causes Control

DOI

EISSN

1573-7225

Publication Date

September 2011

Volume

22

Issue

9

Start / End Page

1217 / 1231

Location

Netherlands

Related Subject Headings

  • Smoking
  • Sex Factors
  • Risk Factors
  • Oropharyngeal Neoplasms
  • Odds Ratio
  • Mouth Neoplasms
  • Male
  • Laryngeal Neoplasms
  • Hypopharyngeal Neoplasms
  • Humans