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A functional variant of tandem repeats in human telomerase gene was associated with survival of patients with early stages of non-small cell lung cancer.

Publication ,  Journal Article
Wang, L; Wang, L-E; Mao, L; Spitz, MR; Wei, Q
Published in: Clin Cancer Res
July 15, 2010

PURPOSE: Elevated levels of human telomerase (hTERT) mRNA in tumors is a marker for poorer survival in patients with stage I non-small cell lung cancer (NSCLC). A functional variant of MNS16A-short tandem repeats in hTERT (S allele) is associated with higher expression levels of hTERT mRNA compared with the MNS16A-long (L) allele. It is unknown, however, whether or not the hTERT MNS16A variant genotype predicts survival of NSCLC patients. EXPERIMENTAL DESIGN: The hTERT genotypes of 808 patients with NSCLC were determined by direct PCR with genomic DNA. Overall median survival times were estimated by the life-table method, and the log-rank test was used to test for homogeneity of the survival curves. Both univariate and multivariate Cox proportional hazards models were used to assess the associations between survival time and the hTERT genotype as well as other known risk factors. RESULTS: The hTERT variant genotype was not associated with overall survival among the 808 patients. However, among 221 patients with stage I or II NSCLC, the S allele was associated with shorter survival time (P = 0.027, by log-rank test). The adjusted hazard ratios were 1.30 (95% confidence interval, 0.79-2.14; P = 0.310) for the SL-genotype and 2.34 (95% confidence interval, 1.20-4.56, P = 0.012) for the SS-genotype compared with the LL-genotype (P = 0.021 for trend test). These findings were not evident in 587 patients with stage III or IV NSCLC. CONCLUSION: The functional MNS16A-SS genotype may be a marker for poorer survival in early-stage NSCLC.

Duke Scholars

Published In

Clin Cancer Res

DOI

EISSN

1557-3265

Publication Date

July 15, 2010

Volume

16

Issue

14

Start / End Page

3779 / 3785

Location

United States

Related Subject Headings

  • Telomerase
  • Tandem Repeat Sequences
  • Survival Rate
  • RNA, Messenger
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
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Wang, L., Wang, L.-E., Mao, L., Spitz, M. R., & Wei, Q. (2010). A functional variant of tandem repeats in human telomerase gene was associated with survival of patients with early stages of non-small cell lung cancer. Clin Cancer Res, 16(14), 3779–3785. https://doi.org/10.1158/1078-0432.CCR-10-0269
Wang, Luo, Li-E Wang, Li Mao, Margaret R. Spitz, and Qingyi Wei. “A functional variant of tandem repeats in human telomerase gene was associated with survival of patients with early stages of non-small cell lung cancer.Clin Cancer Res 16, no. 14 (July 15, 2010): 3779–85. https://doi.org/10.1158/1078-0432.CCR-10-0269.
Wang, Luo, et al. “A functional variant of tandem repeats in human telomerase gene was associated with survival of patients with early stages of non-small cell lung cancer.Clin Cancer Res, vol. 16, no. 14, July 2010, pp. 3779–85. Pubmed, doi:10.1158/1078-0432.CCR-10-0269.

Published In

Clin Cancer Res

DOI

EISSN

1557-3265

Publication Date

July 15, 2010

Volume

16

Issue

14

Start / End Page

3779 / 3785

Location

United States

Related Subject Headings

  • Telomerase
  • Tandem Repeat Sequences
  • Survival Rate
  • RNA, Messenger
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Humans