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Estimation of the effects of smoking and DNA repair capacity on coefficients of a carcinogenesis model for lung cancer.

Publication ,  Journal Article
Deng, L; Kimmel, M; Foy, M; Spitz, M; Wei, Q; Gorlova, O
Published in: Int J Cancer
May 1, 2009

Numerous prospective and retrospective studies have clearly demonstrated a dose-related increased lung cancer risk associated with cigarette smoking, with evidence also for a genetic component to risk. In this study, using the two-stage clonal expansion stochastic model framework, for the first time we investigated the roles of both genetic susceptibility and smoking history in the initiation, clonal expansion, and malignant transformation processes in lung carcinogenesis, integrating information collected by a case-control study and a large-scale prospective cohort study. Our results show that individuals with suboptimal DNA repair capacity have enhanced transition rates of key events in carcinogenesis.

Duke Scholars

Published In

Int J Cancer

DOI

EISSN

1097-0215

Publication Date

May 1, 2009

Volume

124

Issue

9

Start / End Page

2152 / 2158

Location

United States

Related Subject Headings

  • Smoking
  • Risk Factors
  • Risk Assessment
  • Prospective Studies
  • Oncology & Carcinogenesis
  • Models, Statistical
  • Models, Biological
  • Middle Aged
  • Male
  • Lung Neoplasms
 

Citation

APA
Chicago
ICMJE
MLA
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Deng, L., Kimmel, M., Foy, M., Spitz, M., Wei, Q., & Gorlova, O. (2009). Estimation of the effects of smoking and DNA repair capacity on coefficients of a carcinogenesis model for lung cancer. Int J Cancer, 124(9), 2152–2158. https://doi.org/10.1002/ijc.24149
Deng, Li, Marek Kimmel, Millennia Foy, Margaret Spitz, Qingyi Wei, and Olga Gorlova. “Estimation of the effects of smoking and DNA repair capacity on coefficients of a carcinogenesis model for lung cancer.Int J Cancer 124, no. 9 (May 1, 2009): 2152–58. https://doi.org/10.1002/ijc.24149.
Deng L, Kimmel M, Foy M, Spitz M, Wei Q, Gorlova O. Estimation of the effects of smoking and DNA repair capacity on coefficients of a carcinogenesis model for lung cancer. Int J Cancer. 2009 May 1;124(9):2152–8.
Deng, Li, et al. “Estimation of the effects of smoking and DNA repair capacity on coefficients of a carcinogenesis model for lung cancer.Int J Cancer, vol. 124, no. 9, May 2009, pp. 2152–58. Pubmed, doi:10.1002/ijc.24149.
Deng L, Kimmel M, Foy M, Spitz M, Wei Q, Gorlova O. Estimation of the effects of smoking and DNA repair capacity on coefficients of a carcinogenesis model for lung cancer. Int J Cancer. 2009 May 1;124(9):2152–2158.
Journal cover image

Published In

Int J Cancer

DOI

EISSN

1097-0215

Publication Date

May 1, 2009

Volume

124

Issue

9

Start / End Page

2152 / 2158

Location

United States

Related Subject Headings

  • Smoking
  • Risk Factors
  • Risk Assessment
  • Prospective Studies
  • Oncology & Carcinogenesis
  • Models, Statistical
  • Models, Biological
  • Middle Aged
  • Male
  • Lung Neoplasms