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Involuntary smoking and head and neck cancer risk: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium.

Publication ,  Journal Article
Lee, Y-CA; Boffetta, P; Sturgis, EM; Wei, Q; Zhang, Z-F; Muscat, J; Lazarus, P; Matos, E; Hayes, RB; Winn, DM; Zaridze, D; Wünsch-Filho, V ...
Published in: Cancer Epidemiol Biomarkers Prev
August 2008

Although active tobacco smoking has been identified as a major risk factor for head and neck cancer, involuntary smoking has not been adequately evaluated because of the relatively low statistical power in previous studies. We took advantage of data pooled in the International Head and Neck Cancer Epidemiology Consortium to evaluate the role of involuntary smoking in head and neck carcinogenesis. Involuntary smoking exposure data were pooled across six case-control studies in Central Europe, Latin America, and the United States. Adjusted odds ratios (OR) and 95% confidence interval (95% CI) were estimated for 542 cases and 2,197 controls who reported never using tobacco, and the heterogeneity among the study-specific ORs was assessed. In addition, stratified analyses were done by subsite. No effect of ever involuntary smoking exposure either at home or at work was observed for head and neck cancer overall. However, long duration of involuntary smoking exposure at home and at work was associated with an increased risk (OR for >15 years at home, 1.60; 95% CI, 1.12-2.28; P(trend) < 0.01; OR for >15 years at work, 1.55; 95% CI, 1.04-2.30; P(trend) = 0.13). The effect of duration of involuntary smoking exposure at home was stronger for pharyngeal and laryngeal cancers than for other subsites. An association between involuntary smoking exposure and the risk of head and neck cancer, particularly pharyngeal and laryngeal cancers, was observed for long duration of exposure. These results are consistent with those for active smoking and suggest that elimination of involuntary smoking exposure might reduce head and neck cancer risk among never smokers.

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Published In

Cancer Epidemiol Biomarkers Prev

DOI

ISSN

1055-9965

Publication Date

August 2008

Volume

17

Issue

8

Start / End Page

1974 / 1981

Location

United States

Related Subject Headings

  • United States
  • Tobacco Smoke Pollution
  • Risk
  • Middle Aged
  • Male
  • Logistic Models
  • Latin America
  • Humans
  • Head and Neck Neoplasms
  • Female
 

Citation

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Lee, Y.-C., Boffetta, P., Sturgis, E. M., Wei, Q., Zhang, Z.-F., Muscat, J., … Hashibe, M. (2008). Involuntary smoking and head and neck cancer risk: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. Cancer Epidemiol Biomarkers Prev, 17(8), 1974–1981. https://doi.org/10.1158/1055-9965.EPI-08-0047
Lee, Yuan-Chin Amy, Paolo Boffetta, Erich M. Sturgis, Qingyi Wei, Zuo-Feng Zhang, Joshua Muscat, Philip Lazarus, et al. “Involuntary smoking and head and neck cancer risk: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium.Cancer Epidemiol Biomarkers Prev 17, no. 8 (August 2008): 1974–81. https://doi.org/10.1158/1055-9965.EPI-08-0047.
Lee Y-CA, Boffetta P, Sturgis EM, Wei Q, Zhang Z-F, Muscat J, et al. Involuntary smoking and head and neck cancer risk: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. Cancer Epidemiol Biomarkers Prev. 2008 Aug;17(8):1974–81.
Lee, Yuan-Chin Amy, et al. “Involuntary smoking and head and neck cancer risk: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium.Cancer Epidemiol Biomarkers Prev, vol. 17, no. 8, Aug. 2008, pp. 1974–81. Pubmed, doi:10.1158/1055-9965.EPI-08-0047.
Lee Y-CA, Boffetta P, Sturgis EM, Wei Q, Zhang Z-F, Muscat J, Lazarus P, Matos E, Hayes RB, Winn DM, Zaridze D, Wünsch-Filho V, Eluf-Neto J, Koifman S, Mates D, Curado MP, Menezes A, Fernandez L, Daudt AW, Szeszenia-Dabrowska N, Fabianova E, Rudnai P, Ferro G, Berthiller J, Brennan P, Hashibe M. Involuntary smoking and head and neck cancer risk: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. Cancer Epidemiol Biomarkers Prev. 2008 Aug;17(8):1974–1981.

Published In

Cancer Epidemiol Biomarkers Prev

DOI

ISSN

1055-9965

Publication Date

August 2008

Volume

17

Issue

8

Start / End Page

1974 / 1981

Location

United States

Related Subject Headings

  • United States
  • Tobacco Smoke Pollution
  • Risk
  • Middle Aged
  • Male
  • Logistic Models
  • Latin America
  • Humans
  • Head and Neck Neoplasms
  • Female