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The association of polymorphisms of CDT1 and GMNN gene with the risk of breast cancer in Chinese women: a case-control analysis.

Publication ,  Journal Article
Gao, J; Ma, H-X; Zhou, Y; Hu, Z-B; Zhai, X-J; Wang, X-C; Qin, J-W; Chen, W-S; Jin, G-F; Liu, J-Y; Wang, X-R; Tan, Y-F; Wei, Q-Y; Shen, H-B
Published in: Zhonghua Yi Xue Yi Chuan Xue Za Zhi
October 2006

OBJECTIVE: To investigate the association of polymorphisms of CDT1 and GMNN gene, two important genes participating in DNA replication, with the risk of sporadic breast cancer. METHODS: Using polymerase chain reaction-restriction fragment length polymorphism (PCR - RFLP) and the primer-introduced restriction analysis (PIRA)-PCR assay to genotype the CDT1 838G/A and GMNN 387C/A polymorphisms in a case-control study of 427 breast cancer cases and 477 cancer-free controls in a Chinese population. RESULTS: No significant association of the CDT1 838G/A and GMNN 387C/A polymorphisms with the risk of breast cancer was found (adjusted OR:1.16, 95% CI:0.88-1.54 for CDT1 GA+AA genotypes and adjusted OR:0.90, 95% CI:0.67-1.21 for GMNN CA+AA genotypes). However, in the stratified analyses, a significant association of CDT1 GA+AA genotypes with breast cancer risk among subjects with family history of cancer was found (adjusted OR:2.21, 95% CI:1.20-4.09). CONCLUSION: These findings suggest that the CDT1 838G/A and GMNN 387C/A polymorphisms may not play a major role in the etiology of breast cancer, but CDT1 variant may have a potential role only in genetically susceptible women.

Duke Scholars

Published In

Zhonghua Yi Xue Yi Chuan Xue Za Zhi

ISSN

1003-9406

Publication Date

October 2006

Volume

23

Issue

5

Start / End Page

544 / 547

Location

China

Related Subject Headings

  • Polymorphism, Restriction Fragment Length
  • Polymorphism, Genetic
  • Polymerase Chain Reaction
  • Middle Aged
  • Humans
  • Genotype
  • Genetics & Heredity
  • Genetic Predisposition to Disease
  • Gene Frequency
  • Geminin
 

Citation

APA
Chicago
ICMJE
MLA
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Gao, J., Ma, H.-X., Zhou, Y., Hu, Z.-B., Zhai, X.-J., Wang, X.-C., … Shen, H.-B. (2006). The association of polymorphisms of CDT1 and GMNN gene with the risk of breast cancer in Chinese women: a case-control analysis. Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 23(5), 544–547.
Gao, Jun, Hong-xia Ma, Yan Zhou, Zhi-bin Hu, Xiang-jun Zhai, Xue-chen Wang, Jian-wei Qin, et al. “The association of polymorphisms of CDT1 and GMNN gene with the risk of breast cancer in Chinese women: a case-control analysis.Zhonghua Yi Xue Yi Chuan Xue Za Zhi 23, no. 5 (October 2006): 544–47.
Gao J, Ma H-X, Zhou Y, Hu Z-B, Zhai X-J, Wang X-C, et al. The association of polymorphisms of CDT1 and GMNN gene with the risk of breast cancer in Chinese women: a case-control analysis. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2006 Oct;23(5):544–7.
Gao, Jun, et al. “The association of polymorphisms of CDT1 and GMNN gene with the risk of breast cancer in Chinese women: a case-control analysis.Zhonghua Yi Xue Yi Chuan Xue Za Zhi, vol. 23, no. 5, Oct. 2006, pp. 544–47.
Gao J, Ma H-X, Zhou Y, Hu Z-B, Zhai X-J, Wang X-C, Qin J-W, Chen W-S, Jin G-F, Liu J-Y, Wang X-R, Tan Y-F, Wei Q-Y, Shen H-B. The association of polymorphisms of CDT1 and GMNN gene with the risk of breast cancer in Chinese women: a case-control analysis. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2006 Oct;23(5):544–547.

Published In

Zhonghua Yi Xue Yi Chuan Xue Za Zhi

ISSN

1003-9406

Publication Date

October 2006

Volume

23

Issue

5

Start / End Page

544 / 547

Location

China

Related Subject Headings

  • Polymorphism, Restriction Fragment Length
  • Polymorphism, Genetic
  • Polymerase Chain Reaction
  • Middle Aged
  • Humans
  • Genotype
  • Genetics & Heredity
  • Genetic Predisposition to Disease
  • Gene Frequency
  • Geminin