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Dinucleotide polymorphism of p73 gene is associated with a reduced risk of lung cancer in a Chinese population.

Publication ,  Journal Article
Hu, Z; Miao, X; Ma, H; Tan, W; Wang, X; Lu, D; Wei, Q; Lin, D; Shen, H
Published in: Int J Cancer
April 10, 2005

p73, a structural and functional homologue of p53, shares some p53-like tumor suppressor activity but also possesses oncogenic activity. Therefore, p73 plays an important role in modulating cell-cycle control and apoptosis. A potentially functional dinucleotide polymorphism, G4C14-to-A4T14, has been identified in the 5' untranslated region (UTR) of exon 2 of the p73 gene, which may theoretically form a stem-loop structure and affect gene expression. To test the hypothesis that these 2 common variants play a role in lung cancer susceptibility, we conducted a case-control study of 425 lung cancer patients and 588 cancer-free controls frequency-matched to the cases on age and sex in a Chinese population. The results showed that these 2 polymorphisms were in complete linkage disequilibrium and the frequencies of variant p73 AT haplotype (A4T14) were less common in the cases (0.225) than in the controls (0.287) (p = 0.0018), suggesting that this AT haplotype was protective against lung cancer. Compared to the p73 GC/GC homozygotes, both the AT/AT variant homozygotes and GC/AT heterozygotes were associated with a significantly decreased risk (adjusted OR: 0.45, 95% CI: 0.26-0.80 and OR: 0.70, 95% CI: 0.53-0.92, respectively). These results suggest that this p73 dinucleotide polymorphism may have a role in lung cancer susceptibility in our study population. Further studies are needed to elucidate potential functional relevance of the p73 AT variant allele.

Duke Scholars

Published In

Int J Cancer

DOI

ISSN

0020-7136

Publication Date

April 10, 2005

Volume

114

Issue

3

Start / End Page

455 / 460

Location

United States

Related Subject Headings

  • Tumor Suppressor Proteins
  • Tumor Protein p73
  • Risk Factors
  • Polymorphism, Genetic
  • Oncology & Carcinogenesis
  • Odds Ratio
  • Nuclear Proteins
  • Molecular Sequence Data
  • Middle Aged
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
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Hu, Z., Miao, X., Ma, H., Tan, W., Wang, X., Lu, D., … Shen, H. (2005). Dinucleotide polymorphism of p73 gene is associated with a reduced risk of lung cancer in a Chinese population. Int J Cancer, 114(3), 455–460. https://doi.org/10.1002/ijc.20746
Hu, Zhibin, Xiaoping Miao, Hongxia Ma, Wen Tan, Xinru Wang, Daru Lu, Qingyi Wei, Dongxin Lin, and Hongbing Shen. “Dinucleotide polymorphism of p73 gene is associated with a reduced risk of lung cancer in a Chinese population.Int J Cancer 114, no. 3 (April 10, 2005): 455–60. https://doi.org/10.1002/ijc.20746.
Hu Z, Miao X, Ma H, Tan W, Wang X, Lu D, et al. Dinucleotide polymorphism of p73 gene is associated with a reduced risk of lung cancer in a Chinese population. Int J Cancer. 2005 Apr 10;114(3):455–60.
Hu, Zhibin, et al. “Dinucleotide polymorphism of p73 gene is associated with a reduced risk of lung cancer in a Chinese population.Int J Cancer, vol. 114, no. 3, Apr. 2005, pp. 455–60. Pubmed, doi:10.1002/ijc.20746.
Hu Z, Miao X, Ma H, Tan W, Wang X, Lu D, Wei Q, Lin D, Shen H. Dinucleotide polymorphism of p73 gene is associated with a reduced risk of lung cancer in a Chinese population. Int J Cancer. 2005 Apr 10;114(3):455–460.
Journal cover image

Published In

Int J Cancer

DOI

ISSN

0020-7136

Publication Date

April 10, 2005

Volume

114

Issue

3

Start / End Page

455 / 460

Location

United States

Related Subject Headings

  • Tumor Suppressor Proteins
  • Tumor Protein p73
  • Risk Factors
  • Polymorphism, Genetic
  • Oncology & Carcinogenesis
  • Odds Ratio
  • Nuclear Proteins
  • Molecular Sequence Data
  • Middle Aged
  • Male