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Radiation response genotype and risk of differentiated thyroid cancer: a case-control analysis.

Publication ,  Journal Article
Sturgis, EM; Zhao, C; Zheng, R; Wei, Q
Published in: Laryngoscope
June 2005

BACKGROUND: Radiation is the only clear etiologic agent for differentiated thyroid cancer (DTC). Understanding the factors affecting sensitivity to gamma radiation and susceptibility to DTC will be critical to early detection and prevention of DTC. HYPOTHESIS: Germline variants of double-strand break repair genes are markers of DTC risk. OBJECTIVE: Determine the frequency of common single nucleotide polymorphisms of genes of the double-strand break repair pathway in patients with DTC and cancer-free controls. STUDY DESIGN: Case-control study. METHODS: This study included 134 patients with DTC, 79 patients with benign thyroid lesions, and 166 cancer-free control subjects. To avoid ethnic confounding, all subjects were non-Hispanic whites. Genotype analyses were performed on DNA isolated from peripheral blood lymphocytes. Multivariate logistic regression analyses were performed to estimate the risk of DTC associated with each variant genotype. RESULTS: The XRCC3 18067T polymorphic allele was found significantly more commonly among the DTC cases than for the control subjects (P=.006). After multivariate adjustment, having the XRCC3 18067T allele was associated with an increased risk of DTC (adjusted odds ratio [OR] = 2.1; 95% confidence interval [CI] = 1.3 to 3.4; P = .004). In addition, there was a suggestion that the XRCC3 18067T polymorphic allele was more common among the patients with benign thyroid disease (P = .054), and the homozygous polymorphic genotype was associated with risk for benign thyroid disease (adjusted OR = 2.1; 95% CI = 0.9-4.9; P = .078). CONCLUSIONS: In this case-control analysis, the XRCC3 18067T polymorphism is associated with DTC risk. However, such work needs confirmation in larger studies.

Duke Scholars

Published In

Laryngoscope

DOI

ISSN

0023-852X

Publication Date

June 2005

Volume

115

Issue

6

Start / End Page

938 / 945

Location

United States

Related Subject Headings

  • Thyroid Neoplasms
  • Regression Analysis
  • Protein Serine-Threonine Kinases
  • Polymorphism, Single Nucleotide
  • Polymorphism, Genetic
  • Otorhinolaryngology
  • Nuclear Proteins
  • Neoplasms, Radiation-Induced
  • Multivariate Analysis
  • Middle Aged
 

Citation

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Sturgis, E. M., Zhao, C., Zheng, R., & Wei, Q. (2005). Radiation response genotype and risk of differentiated thyroid cancer: a case-control analysis. Laryngoscope, 115(6), 938–945. https://doi.org/10.1097/01.MLG.0000163765.88158.86
Sturgis, Erich M., Chong Zhao, Rong Zheng, and Qingyi Wei. “Radiation response genotype and risk of differentiated thyroid cancer: a case-control analysis.Laryngoscope 115, no. 6 (June 2005): 938–45. https://doi.org/10.1097/01.MLG.0000163765.88158.86.
Sturgis EM, Zhao C, Zheng R, Wei Q. Radiation response genotype and risk of differentiated thyroid cancer: a case-control analysis. Laryngoscope. 2005 Jun;115(6):938–45.
Sturgis, Erich M., et al. “Radiation response genotype and risk of differentiated thyroid cancer: a case-control analysis.Laryngoscope, vol. 115, no. 6, June 2005, pp. 938–45. Pubmed, doi:10.1097/01.MLG.0000163765.88158.86.
Sturgis EM, Zhao C, Zheng R, Wei Q. Radiation response genotype and risk of differentiated thyroid cancer: a case-control analysis. Laryngoscope. 2005 Jun;115(6):938–945.
Journal cover image

Published In

Laryngoscope

DOI

ISSN

0023-852X

Publication Date

June 2005

Volume

115

Issue

6

Start / End Page

938 / 945

Location

United States

Related Subject Headings

  • Thyroid Neoplasms
  • Regression Analysis
  • Protein Serine-Threonine Kinases
  • Polymorphism, Single Nucleotide
  • Polymorphism, Genetic
  • Otorhinolaryngology
  • Nuclear Proteins
  • Neoplasms, Radiation-Induced
  • Multivariate Analysis
  • Middle Aged