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XRCC1 polymorphisms and cancer risk: a meta-analysis of 38 case-control studies.

Publication ,  Journal Article
Hu, Z; Ma, H; Chen, F; Wei, Q; Shen, H
Published in: Cancer Epidemiol Biomarkers Prev
July 2005

Several potential functional polymorphisms (Arg194Trp, Arg280His, Arg399Gln) in the DNA base excision repair gene X-ray repair cross-complementing group 1 (XRCC1) have been implicated in cancer risk. Our meta-analysis on total of 11,957 cancer cases and 14,174 control subjects from 38 published case-control studies showed that the odds ratio (OR) for the variant genotypes (Trp/Trp + Arg/Trp) of the Arg194Trp polymorphism, compared with the wild-type homozygote (Arg/Arg), was 0.89 [95% confidence interval (95% CI), 0.81-0.98] for all tumor types without between-study heterogeneity. Similarly, the overall risk for the combined variant genotypes (His/His + Arg/His) of the Arg280His, compared with the wild homozygote (Arg/Arg), was 1.19 (95% CI, 1.00-1.42). However, there was no main effect in either recessive or dominant modeling for the Arg399Gln, and the variant Gln/Gln homozygote was not associated with overall cancer risk (OR, 1.01; 95% CI, 0.90-1.14). The analyses suggest that XRCC1 Arg194Trp, Arg280His polymorphisms may be biomarkers of cancer susceptibility and a single larger study with thousands of subjects and tissue-specific biochemical and biological characterization is warranted to further evaluate potential gene-to-gene and gene-to-environment interactions on XRCC1 polymorphisms and cancer risk.

Duke Scholars

Published In

Cancer Epidemiol Biomarkers Prev

DOI

ISSN

1055-9965

Publication Date

July 2005

Volume

14

Issue

7

Start / End Page

1810 / 1818

Location

United States

Related Subject Headings

  • X-ray Repair Cross Complementing Protein 1
  • Polymorphism, Genetic
  • Neoplasms
  • Humans
  • Genotype
  • Ethnicity
  • Epidemiology
  • DNA-Binding Proteins
  • Case-Control Studies
  • 42 Health sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hu, Z., Ma, H., Chen, F., Wei, Q., & Shen, H. (2005). XRCC1 polymorphisms and cancer risk: a meta-analysis of 38 case-control studies. Cancer Epidemiol Biomarkers Prev, 14(7), 1810–1818. https://doi.org/10.1158/1055-9965.EPI-04-0793
Hu, Zhibin, Hongxia Ma, Feng Chen, Qingyi Wei, and Hongbing Shen. “XRCC1 polymorphisms and cancer risk: a meta-analysis of 38 case-control studies.Cancer Epidemiol Biomarkers Prev 14, no. 7 (July 2005): 1810–18. https://doi.org/10.1158/1055-9965.EPI-04-0793.
Hu Z, Ma H, Chen F, Wei Q, Shen H. XRCC1 polymorphisms and cancer risk: a meta-analysis of 38 case-control studies. Cancer Epidemiol Biomarkers Prev. 2005 Jul;14(7):1810–8.
Hu, Zhibin, et al. “XRCC1 polymorphisms and cancer risk: a meta-analysis of 38 case-control studies.Cancer Epidemiol Biomarkers Prev, vol. 14, no. 7, July 2005, pp. 1810–18. Pubmed, doi:10.1158/1055-9965.EPI-04-0793.
Hu Z, Ma H, Chen F, Wei Q, Shen H. XRCC1 polymorphisms and cancer risk: a meta-analysis of 38 case-control studies. Cancer Epidemiol Biomarkers Prev. 2005 Jul;14(7):1810–1818.

Published In

Cancer Epidemiol Biomarkers Prev

DOI

ISSN

1055-9965

Publication Date

July 2005

Volume

14

Issue

7

Start / End Page

1810 / 1818

Location

United States

Related Subject Headings

  • X-ray Repair Cross Complementing Protein 1
  • Polymorphism, Genetic
  • Neoplasms
  • Humans
  • Genotype
  • Ethnicity
  • Epidemiology
  • DNA-Binding Proteins
  • Case-Control Studies
  • 42 Health sciences