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Repair of UV light-induced DNA damage and risk of cutaneous malignant melanoma.

Publication ,  Journal Article
Wei, Q; Lee, JE; Gershenwald, JE; Ross, MI; Mansfield, PF; Strom, SS; Wang, L-E; Guo, Z; Qiao, Y; Amos, CI; Spitz, MR; Duvic, M
Published in: J Natl Cancer Inst
February 19, 2003

BACKGROUND: The mechanism underlying the role of UV light exposure from sunlight in the etiology of cutaneous malignant melanoma (CMM) is unclear. Patients with xeroderma pigmentosum, a disease characterized by severe sensitivity to UV radiation and a defect in nucleotide excision repair, have a high incidence of CMM, which suggests that DNA repair capacity (DRC) plays a role in sunlight-induced CMM in the general population as well. METHODS: We conducted a hospital-based case-control study of DRC and CMM among 312 non-Hispanic white CMM patients who had no prior chemotherapy or radiation therapy, and 324 cancer-free control subjects who were frequency-matched to case patients on age, sex, and ethnicity. Information on demographic variables, risk factors, and tumor characteristics was obtained from questionnaires and medical records. We used the host-cell reactivation assay to measure the DRC in study subjects' lymphocytes. All statistical tests were two sided. RESULTS: Case patients had a 19% lower mean (+/- standard deviation [SD]) DRC (8.5 +/- 3.4%) than control subjects (10.5 +/- 5.1%), a statistically significant difference (P<.001). DRC that was at or below the median value (i.e., 9.4%) in control subjects was associated with increased risk for CMM after adjustment for age, sex, and other covariates (odds ratio [OR] = 2.02, 95% confidence interval [CI] = 1.45 to 2.82). We observed a dose-response relationship between decreased DRC and increased risk of CMM (P(trend)<.001). Patients with tumors on sun-exposed skin had statistically significantly lower DRC than patients with tumors on unexposed skin (8.2 +/- 3.3% versus 9.5 +/- 3.5%; P =.004). CONCLUSIONS: Reduced DRC is an independent risk factor for CMM and may contribute to susceptibility to sunlight-induced CMM among the general population.

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Published In

J Natl Cancer Inst

DOI

ISSN

0027-8874

Publication Date

February 19, 2003

Volume

95

Issue

4

Start / End Page

308 / 315

Location

United States

Related Subject Headings

  • Ultraviolet Rays
  • Sunlight
  • Skin Neoplasms
  • Risk Factors
  • Risk Assessment
  • Oncology & Carcinogenesis
  • Odds Ratio
  • Middle Aged
  • Melanoma
  • Male
 

Citation

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Wei, Q., Lee, J. E., Gershenwald, J. E., Ross, M. I., Mansfield, P. F., Strom, S. S., … Duvic, M. (2003). Repair of UV light-induced DNA damage and risk of cutaneous malignant melanoma. J Natl Cancer Inst, 95(4), 308–315. https://doi.org/10.1093/jnci/95.4.308
Wei, Qingyi, Jeffrey E. Lee, Jeffrey E. Gershenwald, Merrick I. Ross, Paul F. Mansfield, Sara S. Strom, Li-E Wang, et al. “Repair of UV light-induced DNA damage and risk of cutaneous malignant melanoma.J Natl Cancer Inst 95, no. 4 (February 19, 2003): 308–15. https://doi.org/10.1093/jnci/95.4.308.
Wei Q, Lee JE, Gershenwald JE, Ross MI, Mansfield PF, Strom SS, et al. Repair of UV light-induced DNA damage and risk of cutaneous malignant melanoma. J Natl Cancer Inst. 2003 Feb 19;95(4):308–15.
Wei, Qingyi, et al. “Repair of UV light-induced DNA damage and risk of cutaneous malignant melanoma.J Natl Cancer Inst, vol. 95, no. 4, Feb. 2003, pp. 308–15. Pubmed, doi:10.1093/jnci/95.4.308.
Wei Q, Lee JE, Gershenwald JE, Ross MI, Mansfield PF, Strom SS, Wang L-E, Guo Z, Qiao Y, Amos CI, Spitz MR, Duvic M. Repair of UV light-induced DNA damage and risk of cutaneous malignant melanoma. J Natl Cancer Inst. 2003 Feb 19;95(4):308–315.
Journal cover image

Published In

J Natl Cancer Inst

DOI

ISSN

0027-8874

Publication Date

February 19, 2003

Volume

95

Issue

4

Start / End Page

308 / 315

Location

United States

Related Subject Headings

  • Ultraviolet Rays
  • Sunlight
  • Skin Neoplasms
  • Risk Factors
  • Risk Assessment
  • Oncology & Carcinogenesis
  • Odds Ratio
  • Middle Aged
  • Melanoma
  • Male