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Aberrant monocyte prostaglandin synthase 2 (PGS2) expression in type 1 diabetes before and after disease onset.

Publication ,  Journal Article
Litherland, SA; She, JX; Schatz, D; Fuller, K; Hutson, AD; Peng, RH; Li, Y; Grebe, KM; Whittaker, DS; Bahjat, K; Hopkins, D; Fang, Q; Cook, R ...
Published in: Pediatr Diabetes
March 2003

METHODS: We examined monocyte prostaglandin synthase 2 (PGS2/COX2) expression in individuals at risk for or with type 1 diabetes including: (i) 58 established type 1 and 2 diabetic patients; (ii) 34 autoantibody positive (AA+) children and adults; (iii) 164 infants and young children with insulin-dependent diabetes mellitus (IDDM) susceptibility human leukocyte antigen (HLA) alleles; and (iv) 37 healthy control individuals, over a 5-yr period. RESULTS: Established type 1 diabetic patients (1 month to 30+ yr post-disease onset) had significantly higher PGS2 expression than healthy controls; by contrast, insulin-treated type 2 diabetic patients had significantly lower PGS2 expression than healthy controls. Longitudinal studies of AA+ subjects at risk for type 1 diabetes indicated that 73% (11/15) of individuals who developed this disease during the study period expressed high levels of PGS2 prior to or after onset. We also found high level PGS2 expression in genetically at-risk infants and young children that correlated with having a first-degree relative with type 1 diabetes, but not with age, gender, or HLA genotype. In this population, high level PGS2 expression coincided with or preceded autoantibody detection in 30% (3/10) of subjects. CONCLUSIONS: These findings suggest that high level monocyte PGS2 expression, although subject to fluctuation, is present in at-risk subjects at an early age and is maintained during progression to and after type 1 diabetes onset.

Duke Scholars

Published In

Pediatr Diabetes

DOI

ISSN

1399-543X

Publication Date

March 2003

Volume

4

Issue

1

Start / End Page

10 / 18

Location

Denmark

Related Subject Headings

  • Prostaglandin-Endoperoxide Synthases
  • Monocytes
  • Membrane Proteins
  • Male
  • Isoenzymes
  • Infant
  • Humans
  • HLA Antigens
  • Genotype
  • Genetic Predisposition to Disease
 

Citation

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Litherland, S. A., She, J. X., Schatz, D., Fuller, K., Hutson, A. D., Peng, R. H., … Clare-Salzler, M. J. (2003). Aberrant monocyte prostaglandin synthase 2 (PGS2) expression in type 1 diabetes before and after disease onset. Pediatr Diabetes, 4(1), 10–18. https://doi.org/10.1034/j.1399-5448.2003.00042.x
Litherland, S. A., J. X. She, D. Schatz, K. Fuller, A. D. Hutson, R. H. Peng, Y. Li, et al. “Aberrant monocyte prostaglandin synthase 2 (PGS2) expression in type 1 diabetes before and after disease onset.Pediatr Diabetes 4, no. 1 (March 2003): 10–18. https://doi.org/10.1034/j.1399-5448.2003.00042.x.
Litherland SA, She JX, Schatz D, Fuller K, Hutson AD, Peng RH, et al. Aberrant monocyte prostaglandin synthase 2 (PGS2) expression in type 1 diabetes before and after disease onset. Pediatr Diabetes. 2003 Mar;4(1):10–8.
Litherland, S. A., et al. “Aberrant monocyte prostaglandin synthase 2 (PGS2) expression in type 1 diabetes before and after disease onset.Pediatr Diabetes, vol. 4, no. 1, Mar. 2003, pp. 10–18. Pubmed, doi:10.1034/j.1399-5448.2003.00042.x.
Litherland SA, She JX, Schatz D, Fuller K, Hutson AD, Peng RH, Li Y, Grebe KM, Whittaker DS, Bahjat K, Hopkins D, Fang Q, Spies PD, North K, Wasserfall C, Cook R, Dennis MA, Crockett S, Sleasman J, Kocher J, Muir A, Silverstein J, Atkinson M, Clare-Salzler MJ. Aberrant monocyte prostaglandin synthase 2 (PGS2) expression in type 1 diabetes before and after disease onset. Pediatr Diabetes. 2003 Mar;4(1):10–18.
Journal cover image

Published In

Pediatr Diabetes

DOI

ISSN

1399-543X

Publication Date

March 2003

Volume

4

Issue

1

Start / End Page

10 / 18

Location

Denmark

Related Subject Headings

  • Prostaglandin-Endoperoxide Synthases
  • Monocytes
  • Membrane Proteins
  • Male
  • Isoenzymes
  • Infant
  • Humans
  • HLA Antigens
  • Genotype
  • Genetic Predisposition to Disease