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Obese patients have lower B-type and atrial natriuretic peptide levels compared with nonobese.

Publication ,  Journal Article
Khush, KK; Gerber, IL; McKeown, B; Marcus, G; Vessey, J; Foster, E; Chatterjee, K; Michaels, AD
Published in: Congest Heart Fail
2006

Obesity is a risk factor for the development of heart failure, but the causal mechanism remains unclear. Impaired production or enhanced clearance of natriuretic peptides, which regulate sodium balance and sympathetic activation, may play an important role. The authors investigated the relationship of plasma B-type natriuretic peptide and atrial natriuretic peptide levels to body mass index in 100 patients referred for left heart catheterization. Hemodynamic and echocardiographic data were obtained for all study participants. Atrial natriuretic peptide and B-type natriuretic peptide levels were compared in obese (body mass index > or = 30 kg/m2) and nonobese (body mass index < 30 kg/m2) subjects. Multivariate regression analyses were performed, adjusting for clinical and hemodynamic covariates. Obese patients had significantly lower B-type natriuretic peptide (p = 0.03) and atrial natriuretic peptide (p = 0.04) levels compared with nonobese. Multivariate analysis revealed lower B-type natriuretic peptide (p = 0.095) and atrial natriuretic peptide (p = 0.007) levels in obese patients while controlling for age, sex, left ventricular end-diastolic pressure, and left ventricular ejection fraction. Low levels of circulating natriuretic peptides are thus associated with obesity and may contribute to the development of heart failure.

Duke Scholars

Published In

Congest Heart Fail

DOI

ISSN

1527-5299

Publication Date

2006

Volume

12

Issue

2

Start / End Page

85 / 90

Location

United States

Related Subject Headings

  • Risk Factors
  • Risk Assessment
  • Obesity
  • Natriuretic Peptide, Brain
  • Middle Aged
  • Male
  • Humans
  • Hemodynamics
  • Female
  • Case-Control Studies
 

Citation

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MLA
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Khush, K. K., Gerber, I. L., McKeown, B., Marcus, G., Vessey, J., Foster, E., … Michaels, A. D. (2006). Obese patients have lower B-type and atrial natriuretic peptide levels compared with nonobese. Congest Heart Fail, 12(2), 85–90. https://doi.org/10.1111/j.1527-5299.2006.04900.x
Khush, Kiran K., Ivor L. Gerber, Barry McKeown, Gregory Marcus, Joshua Vessey, Elyse Foster, Kanu Chatterjee, and Andrew D. Michaels. “Obese patients have lower B-type and atrial natriuretic peptide levels compared with nonobese.Congest Heart Fail 12, no. 2 (2006): 85–90. https://doi.org/10.1111/j.1527-5299.2006.04900.x.
Khush KK, Gerber IL, McKeown B, Marcus G, Vessey J, Foster E, et al. Obese patients have lower B-type and atrial natriuretic peptide levels compared with nonobese. Congest Heart Fail. 2006;12(2):85–90.
Khush, Kiran K., et al. “Obese patients have lower B-type and atrial natriuretic peptide levels compared with nonobese.Congest Heart Fail, vol. 12, no. 2, 2006, pp. 85–90. Pubmed, doi:10.1111/j.1527-5299.2006.04900.x.
Khush KK, Gerber IL, McKeown B, Marcus G, Vessey J, Foster E, Chatterjee K, Michaels AD. Obese patients have lower B-type and atrial natriuretic peptide levels compared with nonobese. Congest Heart Fail. 2006;12(2):85–90.

Published In

Congest Heart Fail

DOI

ISSN

1527-5299

Publication Date

2006

Volume

12

Issue

2

Start / End Page

85 / 90

Location

United States

Related Subject Headings

  • Risk Factors
  • Risk Assessment
  • Obesity
  • Natriuretic Peptide, Brain
  • Middle Aged
  • Male
  • Humans
  • Hemodynamics
  • Female
  • Case-Control Studies