Skip to main content

Recent advances in juvenile idiopathic inflammatory myopathies.

Publication ,  Journal Article
Ernste, FC; Reed, AM
Published in: Curr Opin Rheumatol
November 2014

PURPOSE OF REVIEW: Ongoing research continues to advance our understanding of the juvenile idiopathic inflammatory myopathies (JIIMs). We review the recent contributions from the published literature about the classification, pathogenesis, assessment, and treatment of JIIMs in basic and translational science and clinical research in 2013 through early 2014. RECENT FINDINGS: Large registries, such as the Childhood Arthritis and Rheumatology Research Alliance registry, are conducting trials to enhance our understanding of JIIMs. Ultraviolet radiation exposure 1 month prior to juvenile dermatomyositis (JDM) may trigger the onset of disease. Myositis-specific autoantibodies define clinical phenotypes in JIIMs. MRI is useful in diagnosing JDM and may be used as a disease assessment tool. Type 1 interferon genes and proteins are increasing in use as disease assessment tools, but larger, prospective, validation studies are needed. Moderate-to-intense physical activity is effective in increasing the aerobic capacity of JDM patients in remission. New criteria developed by the Paediatric Rheumatology International Trials Organization for classifying inactive disease in JDM have practical applicability to the current clinical practice and clinical trials as even after 16.8 years of symptom onset, over half of JDM patients still have active disease. SUMMARY: There has been significant progress in understanding the clinical characteristics, diagnostic workup, treatment, disease assessment, and prognosis of JIIM patients, but more prospective treatment trials are needed, especially in light of the paucity of the current biologic treatment agents available.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Curr Opin Rheumatol

DOI

EISSN

1531-6963

Publication Date

November 2014

Volume

26

Issue

6

Start / End Page

671 / 678

Location

United States

Related Subject Headings

  • Prognosis
  • Phenotype
  • Myositis
  • Humans
  • Child
  • Arthritis & Rheumatology
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ernste, F. C., & Reed, A. M. (2014). Recent advances in juvenile idiopathic inflammatory myopathies. Curr Opin Rheumatol, 26(6), 671–678. https://doi.org/10.1097/BOR.0000000000000103
Ernste, Floranne C., and Ann M. Reed. “Recent advances in juvenile idiopathic inflammatory myopathies.Curr Opin Rheumatol 26, no. 6 (November 2014): 671–78. https://doi.org/10.1097/BOR.0000000000000103.
Ernste FC, Reed AM. Recent advances in juvenile idiopathic inflammatory myopathies. Curr Opin Rheumatol. 2014 Nov;26(6):671–8.
Ernste, Floranne C., and Ann M. Reed. “Recent advances in juvenile idiopathic inflammatory myopathies.Curr Opin Rheumatol, vol. 26, no. 6, Nov. 2014, pp. 671–78. Pubmed, doi:10.1097/BOR.0000000000000103.
Ernste FC, Reed AM. Recent advances in juvenile idiopathic inflammatory myopathies. Curr Opin Rheumatol. 2014 Nov;26(6):671–678.

Published In

Curr Opin Rheumatol

DOI

EISSN

1531-6963

Publication Date

November 2014

Volume

26

Issue

6

Start / End Page

671 / 678

Location

United States

Related Subject Headings

  • Prognosis
  • Phenotype
  • Myositis
  • Humans
  • Child
  • Arthritis & Rheumatology
  • 3202 Clinical sciences
  • 1103 Clinical Sciences