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Evaluation of muscles affected by myositis using magnetic resonance elastography.

Publication ,  Journal Article
McCullough, MB; Domire, ZJ; Reed, AM; Amin, S; Ytterberg, SR; Chen, Q; An, K-N
Published in: Muscle Nerve
April 2011

INTRODUCTION: Idiopathic inflammatory myopathies (IIMs, or myositis) represent a group of autoimmune diseases that result in decreased muscle strength and/or endurance. Non-invasive tools to assess muscle may improve our understanding of the clinical and functional consequences of myopathies and their response to treatment. In this study we examine magnetic resonance elastography (MRE), a non-invasive technique that assesses the shear modulus (stiffness) of muscle, in IIM subjects. METHODS: Nine subjects with active myositis completed the MRE protocol. Participants lay in a positioning device, and scans of the vastus medialis (VM) were taken in the relaxed state and at two contraction levels. Manual inversion was used to estimate the stiffness. RESULTS: A significant reduction in muscle stiffness was seen in myositis subjects compared with healthy controls during the "relaxed" condition. DISCUSSION: The use of non-invasive technologies such as MRE may provide greater understanding of the pathophysiology of IIM and improve assessment of treatment efficacy.

Duke Scholars

Published In

Muscle Nerve

DOI

EISSN

1097-4598

Publication Date

April 2011

Volume

43

Issue

4

Start / End Page

585 / 590

Location

United States

Related Subject Headings

  • Neurology & Neurosurgery
  • Myositis
  • Muscle, Skeletal
  • Middle Aged
  • Male
  • Humans
  • Female
  • Elasticity Imaging Techniques
  • Child
  • Aged
 

Citation

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ICMJE
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McCullough, M. B., Domire, Z. J., Reed, A. M., Amin, S., Ytterberg, S. R., Chen, Q., & An, K.-N. (2011). Evaluation of muscles affected by myositis using magnetic resonance elastography. Muscle Nerve, 43(4), 585–590. https://doi.org/10.1002/mus.21923
McCullough, Matthew B., Zachary J. Domire, Ann M. Reed, Shreyasee Amin, Steven R. Ytterberg, Qingshan Chen, and Kai-Nan An. “Evaluation of muscles affected by myositis using magnetic resonance elastography.Muscle Nerve 43, no. 4 (April 2011): 585–90. https://doi.org/10.1002/mus.21923.
McCullough MB, Domire ZJ, Reed AM, Amin S, Ytterberg SR, Chen Q, et al. Evaluation of muscles affected by myositis using magnetic resonance elastography. Muscle Nerve. 2011 Apr;43(4):585–90.
McCullough, Matthew B., et al. “Evaluation of muscles affected by myositis using magnetic resonance elastography.Muscle Nerve, vol. 43, no. 4, Apr. 2011, pp. 585–90. Pubmed, doi:10.1002/mus.21923.
McCullough MB, Domire ZJ, Reed AM, Amin S, Ytterberg SR, Chen Q, An K-N. Evaluation of muscles affected by myositis using magnetic resonance elastography. Muscle Nerve. 2011 Apr;43(4):585–590.
Journal cover image

Published In

Muscle Nerve

DOI

EISSN

1097-4598

Publication Date

April 2011

Volume

43

Issue

4

Start / End Page

585 / 590

Location

United States

Related Subject Headings

  • Neurology & Neurosurgery
  • Myositis
  • Muscle, Skeletal
  • Middle Aged
  • Male
  • Humans
  • Female
  • Elasticity Imaging Techniques
  • Child
  • Aged