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Genetic and environmental risk factors for idiopathic inflammatory myopathies.

Publication ,  Journal Article
Reed, AM; Ytterberg, SR
Published in: Rheum Dis Clin North Am
November 2002

Although the studies discussed are beginning to reveal a number of genetic and possible environmental risk factors for myositis, further investigations are needed to fully understand and classify these syndromes. The difficulties in this process include small numbers of subjects with varying disease phenotypes available for study, polygenic risk factors for which it remains unclear which are primary and which are secondary or linked genes, and the lack of validated environmental exposure assessment tools. New technologies and international collaborative approaches, however, may overcome some of these difficulties and allow us to identify genetic and environmental risk factors, as well as the critical gene-environment interactions in the IIM and its subgroups. Nonetheless, our understanding of these diseases is still in the early stages. Although we have learned a great deal about these disorders through detailed investigations over the last several decades, we have even further to go to understand the environmental triggers and genetic susceptibilities for the myositis syndromes.

Duke Scholars

Published In

Rheum Dis Clin North Am

DOI

ISSN

0889-857X

Publication Date

November 2002

Volume

28

Issue

4

Start / End Page

891 / 916

Location

United States

Related Subject Headings

  • Risk Factors
  • Myositis
  • Humans
  • Genetic Predisposition to Disease
  • Environmental Exposure
  • Cohort Studies
  • Arthritis & Rheumatology
  • Animals
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Reed, A. M., & Ytterberg, S. R. (2002). Genetic and environmental risk factors for idiopathic inflammatory myopathies. Rheum Dis Clin North Am, 28(4), 891–916. https://doi.org/10.1016/s0889-857x(02)00029-7
Reed, Ann M., and Steven R. Ytterberg. “Genetic and environmental risk factors for idiopathic inflammatory myopathies.Rheum Dis Clin North Am 28, no. 4 (November 2002): 891–916. https://doi.org/10.1016/s0889-857x(02)00029-7.
Reed AM, Ytterberg SR. Genetic and environmental risk factors for idiopathic inflammatory myopathies. Rheum Dis Clin North Am. 2002 Nov;28(4):891–916.
Reed, Ann M., and Steven R. Ytterberg. “Genetic and environmental risk factors for idiopathic inflammatory myopathies.Rheum Dis Clin North Am, vol. 28, no. 4, Nov. 2002, pp. 891–916. Pubmed, doi:10.1016/s0889-857x(02)00029-7.
Reed AM, Ytterberg SR. Genetic and environmental risk factors for idiopathic inflammatory myopathies. Rheum Dis Clin North Am. 2002 Nov;28(4):891–916.
Journal cover image

Published In

Rheum Dis Clin North Am

DOI

ISSN

0889-857X

Publication Date

November 2002

Volume

28

Issue

4

Start / End Page

891 / 916

Location

United States

Related Subject Headings

  • Risk Factors
  • Myositis
  • Humans
  • Genetic Predisposition to Disease
  • Environmental Exposure
  • Cohort Studies
  • Arthritis & Rheumatology
  • Animals
  • 3202 Clinical sciences
  • 1103 Clinical Sciences