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Development of validated disease activity and damage indices for the juvenile idiopathic inflammatory myopathies: I. Physician, parent, and patient global assessments. Juvenile Dermatomyositis Disease Activity Collaborative Study Group.

Publication ,  Journal Article
Rider, LG; Feldman, BM; Perez, MD; Rennebohm, RM; Lindsley, CB; Zemel, LS; Wallace, CA; Ballinger, SH; Bowyer, SL; Reed, AM; Passo, MH ...
Published in: Arthritis Rheum
November 1997

OBJECTIVE: To determine the reliability, content validity, and responsiveness of physician global assessments of disease activity and damage in the juvenile idiopathic inflammatory myopathies (IIM), and to investigate concordance among physician, parent, and patient global ratings. METHODS: Sixteen pediatric rheumatologists rated 10 juvenile IIM paper patient cases for global disease activity and damage, and assessed the importance of 51 clinical and laboratory parameters in formulating their global assessments. Then, 117 juvenile IIM patients were enrolled in a protocol to examine the relationship between Likert and visual analog scale global assessments, their sensitivity to change, and the comparability of physician, parent, and patient global ratings. RESULTS: Pediatric rheumatologists demonstrated excellent interrater reliability in their global assessments of juvenile IIM disease activity and damage (97.7% and 94.7% agreement among raters, respectively), and agreed on a core set of clinical parameters in formulating their judgments. Likert scale ratings correlated with those on a visual analog scale, and both were comparable in responsiveness (standardized response means -0.56 for disease activity, 0.02 [Likert] and 0.14 [visual analog] for damage, measured over 8 months). Parent global ratings of disease activity correlated with physician assessments, but were not colinear (Spearman's correlation [r] = 0.41-0.45). Patient global disease activity assessments correlated with those done by parents (r = 0.57-0.84) and physicians (r = 0.37-0.63), but demonstrated less responsiveness (standardized response means -0.21 and -0.12, respectively, over 8 months). CONCLUSION: Physician global assessments of juvenile IIM disease activity and damage demonstrated high interrater reliability and were shown to be comprehensive measures. Both physician and parent disease activity assessments should be considered valuable as quantitative measures for evaluating therapeutic responses in juvenile IIM patients.

Duke Scholars

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Published In

Arthritis Rheum

DOI

ISSN

0004-3591

Publication Date

November 1997

Volume

40

Issue

11

Start / End Page

1976 / 1983

Location

United States

Related Subject Headings

  • Severity of Illness Index
  • Reproducibility of Results
  • Physicians
  • Patients
  • Parents
  • Pain Measurement
  • Observer Variation
  • Humans
  • Child, Preschool
  • Child
 

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Rider, L. G., Feldman, B. M., Perez, M. D., Rennebohm, R. M., Lindsley, C. B., Zemel, L. S., … Lachenbruch, P. A. (1997). Development of validated disease activity and damage indices for the juvenile idiopathic inflammatory myopathies: I. Physician, parent, and patient global assessments. Juvenile Dermatomyositis Disease Activity Collaborative Study Group. Arthritis Rheum, 40(11), 1976–1983. https://doi.org/10.1002/art.1780401109
Rider, L. G., B. M. Feldman, M. D. Perez, R. M. Rennebohm, C. B. Lindsley, L. S. Zemel, C. A. Wallace, et al. “Development of validated disease activity and damage indices for the juvenile idiopathic inflammatory myopathies: I. Physician, parent, and patient global assessments. Juvenile Dermatomyositis Disease Activity Collaborative Study Group.Arthritis Rheum 40, no. 11 (November 1997): 1976–83. https://doi.org/10.1002/art.1780401109.
Rider LG, Feldman BM, Perez MD, Rennebohm RM, Lindsley CB, Zemel LS, Wallace CA, Ballinger SH, Bowyer SL, Reed AM, Passo MH, Katona IM, Miller FW, Lachenbruch PA. Development of validated disease activity and damage indices for the juvenile idiopathic inflammatory myopathies: I. Physician, parent, and patient global assessments. Juvenile Dermatomyositis Disease Activity Collaborative Study Group. Arthritis Rheum. 1997 Nov;40(11):1976–1983.
Journal cover image

Published In

Arthritis Rheum

DOI

ISSN

0004-3591

Publication Date

November 1997

Volume

40

Issue

11

Start / End Page

1976 / 1983

Location

United States

Related Subject Headings

  • Severity of Illness Index
  • Reproducibility of Results
  • Physicians
  • Patients
  • Parents
  • Pain Measurement
  • Observer Variation
  • Humans
  • Child, Preschool
  • Child