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Detection of clinical and subclinical retinal abnormalities in neurosarcoidosis with optical coherence tomography.

Publication ,  Journal Article
Eckstein, C; Saidha, S; Sotirchos, ES; Byraiah, G; Seigo, M; Stankiewicz, A; Syc, SB; Ford, E; Sharma, S; Calabresi, PA; Pardo, CA
Published in: J Neurol
July 2012

The aim of this work was to determine if neurosarcoidosis (NS) patients exhibit quantitative and/or qualitative in vivo evidence of retinal abnormalities on optical coherence tomography (OCT). Retinal imaging was performed using spectral-domain Cirrus HD-OCT in 20 NS patients (40 eyes) and 24 age-matched healthy controls (48 eyes). Study participants also underwent magnetic resonance imaging of the brain and spine, cerebrospinal fluid (CSF) analysis, and detailed neurological and ophthalmological evaluation. Quantitative OCT abnormalities of average macular thickness (AMT), peri-papillary retinal nerve fiber layer (RNFL) thickness, or both, were detectable in 60% of NS patients. Of NS patients with ocular symptomatology, 75% demonstrated quantitative OCT abnormalities, while only 25% had detectable abnormalities on detailed ophthalmological assessment. Furthermore, 33% of NS patients without ocular symptoms had quantitative OCT changes, while only 8% had abnormal ophthalmologic examination. RNFL and macular thinning and swelling were significant in the NS cohort compared to healthy controls (variance ratio testing; RNFL: p = 0.02, AMT: p = 0.006). AMT also correlated inversely with disease duration (r (s) = -0.65, p = 0.002). Patient proportions with OCT abnormalities did not differ according to NS subtype (myelopathic, meningeal, or encephalitic NS), CSF findings, or immunotherapy exposure. No qualitative OCT abnormalities were detected. Retinal abnormalities occur in all NS subtypes, and may be clinical or subclinical. Our findings suggest OCT may enable greater detection of retinal abnormalities in NS than ophthalmological assessment alone, and have implications for the assessment of ocular involvement in NS, and sarcoidosis in general. Longitudinal NS studies utilizing OCT are warranted.

Duke Scholars

Published In

J Neurol

DOI

EISSN

1432-1459

Publication Date

July 2012

Volume

259

Issue

7

Start / End Page

1390 / 1398

Location

Germany

Related Subject Headings

  • Tomography, Optical Coherence
  • Statistics, Nonparametric
  • Spinal Cord Diseases
  • Sarcoidosis
  • Retinal Diseases
  • Retina
  • Neurology & Neurosurgery
  • Nerve Fibers
  • Middle Aged
  • Male
 

Citation

APA
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ICMJE
MLA
NLM
Eckstein, C., Saidha, S., Sotirchos, E. S., Byraiah, G., Seigo, M., Stankiewicz, A., … Pardo, C. A. (2012). Detection of clinical and subclinical retinal abnormalities in neurosarcoidosis with optical coherence tomography. J Neurol, 259(7), 1390–1398. https://doi.org/10.1007/s00415-011-6363-8
Eckstein, Christopher, Shiv Saidha, Elias S. Sotirchos, Gita Byraiah, Michaela Seigo, Aleksandra Stankiewicz, Stephanie B. Syc, et al. “Detection of clinical and subclinical retinal abnormalities in neurosarcoidosis with optical coherence tomography.J Neurol 259, no. 7 (July 2012): 1390–98. https://doi.org/10.1007/s00415-011-6363-8.
Eckstein C, Saidha S, Sotirchos ES, Byraiah G, Seigo M, Stankiewicz A, et al. Detection of clinical and subclinical retinal abnormalities in neurosarcoidosis with optical coherence tomography. J Neurol. 2012 Jul;259(7):1390–8.
Eckstein, Christopher, et al. “Detection of clinical and subclinical retinal abnormalities in neurosarcoidosis with optical coherence tomography.J Neurol, vol. 259, no. 7, July 2012, pp. 1390–98. Pubmed, doi:10.1007/s00415-011-6363-8.
Eckstein C, Saidha S, Sotirchos ES, Byraiah G, Seigo M, Stankiewicz A, Syc SB, Ford E, Sharma S, Calabresi PA, Pardo CA. Detection of clinical and subclinical retinal abnormalities in neurosarcoidosis with optical coherence tomography. J Neurol. 2012 Jul;259(7):1390–1398.
Journal cover image

Published In

J Neurol

DOI

EISSN

1432-1459

Publication Date

July 2012

Volume

259

Issue

7

Start / End Page

1390 / 1398

Location

Germany

Related Subject Headings

  • Tomography, Optical Coherence
  • Statistics, Nonparametric
  • Spinal Cord Diseases
  • Sarcoidosis
  • Retinal Diseases
  • Retina
  • Neurology & Neurosurgery
  • Nerve Fibers
  • Middle Aged
  • Male