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New and emerging disease modifying therapies for multiple sclerosis.

Publication ,  Journal Article
Saidha, S; Eckstein, C; Calabresi, PA
Published in: Ann N Y Acad Sci
January 2012

Several disease-modifying drugs (DMDs) are currently approved for the treatment of multiple sclerosis (MS). Recently, there has been increased identification and development of potential new treatments that may modulate the MS disease process, including oral therapies. Many of the newly approved MS therapies, as well as those in ongoing clinical trials, have the advantage of improved efficacy and/or being oral and more convenient, as compared to conventional injectable first-line MS therapies. However, many of these new and emerging MS treatments are known to be associated with serious adverse events, some of which may be potentially life threatening. Of additional concern, there is limited experience and long-term safety data for many of these drugs, and thus the true potential for complications associated with these agents remains ambiguous. With an anticipated explosion in the artillery of available MS therapies in the near future, neurologists will need to carefully weigh drug efficacy, convenience, safety, and tolerability when making therapeutic decisions. In this review, we describe the known mechanisms of action, efficacy, and side-effect profiles of new and emerging MS DMDs.

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Published In

Ann N Y Acad Sci

DOI

EISSN

1749-6632

Publication Date

January 2012

Volume

1247

Start / End Page

117 / 137

Location

United States

Related Subject Headings

  • Multiple Sclerosis
  • Immunosuppressive Agents
  • Humans
  • General Science & Technology
  • Administration, Oral
 

Citation

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Saidha, S., Eckstein, C., & Calabresi, P. A. (2012). New and emerging disease modifying therapies for multiple sclerosis. Ann N Y Acad Sci, 1247, 117–137. https://doi.org/10.1111/j.1749-6632.2011.06272.x
Saidha, Shiv, Christopher Eckstein, and Peter A. Calabresi. “New and emerging disease modifying therapies for multiple sclerosis.Ann N Y Acad Sci 1247 (January 2012): 117–37. https://doi.org/10.1111/j.1749-6632.2011.06272.x.
Saidha S, Eckstein C, Calabresi PA. New and emerging disease modifying therapies for multiple sclerosis. Ann N Y Acad Sci. 2012 Jan;1247:117–37.
Saidha, Shiv, et al. “New and emerging disease modifying therapies for multiple sclerosis.Ann N Y Acad Sci, vol. 1247, Jan. 2012, pp. 117–37. Pubmed, doi:10.1111/j.1749-6632.2011.06272.x.
Saidha S, Eckstein C, Calabresi PA. New and emerging disease modifying therapies for multiple sclerosis. Ann N Y Acad Sci. 2012 Jan;1247:117–137.
Journal cover image

Published In

Ann N Y Acad Sci

DOI

EISSN

1749-6632

Publication Date

January 2012

Volume

1247

Start / End Page

117 / 137

Location

United States

Related Subject Headings

  • Multiple Sclerosis
  • Immunosuppressive Agents
  • Humans
  • General Science & Technology
  • Administration, Oral