Top-down suppression deficit underlies working memory impairment in normal aging.
Publication
, Journal Article
Gazzaley, A; Cooney, JW; Rissman, J; D'Esposito, M
Published in: Nat Neurosci
October 2005
In this study, we assess the impact of normal aging on top-down modulation, a cognitive control mechanism that supports both attention and memory by the suppression and enhancement of sensory processing in accordance with task goals. Using fMRI (functional magnetic resonance imaging), we show that healthy older adults demonstrated a prominent deficit in the suppression of cortical activity associated with task-irrelevant representations, whereas enhancement of task-relevant activity was preserved. Moreover, this suppression-specific attention deficit correlated with impaired working memory performance.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
Nat Neurosci
DOI
ISSN
1097-6256
Publication Date
October 2005
Volume
8
Issue
10
Start / End Page
1298 / 1300
Location
United States
Related Subject Headings
- Time Factors
- Photic Stimulation
- Oxygen
- Neuropsychological Tests
- Neurology & Neurosurgery
- Middle Aged
- Memory, Short-Term
- Memory Disorders
- Male
- Magnetic Resonance Imaging
Citation
APA
Chicago
ICMJE
MLA
NLM
Gazzaley, A., Cooney, J. W., Rissman, J., & D’Esposito, M. (2005). Top-down suppression deficit underlies working memory impairment in normal aging. Nat Neurosci, 8(10), 1298–1300. https://doi.org/10.1038/nn1543
Gazzaley, Adam, Jeffrey W. Cooney, Jesse Rissman, and Mark D’Esposito. “Top-down suppression deficit underlies working memory impairment in normal aging.” Nat Neurosci 8, no. 10 (October 2005): 1298–1300. https://doi.org/10.1038/nn1543.
Gazzaley A, Cooney JW, Rissman J, D’Esposito M. Top-down suppression deficit underlies working memory impairment in normal aging. Nat Neurosci. 2005 Oct;8(10):1298–300.
Gazzaley, Adam, et al. “Top-down suppression deficit underlies working memory impairment in normal aging.” Nat Neurosci, vol. 8, no. 10, Oct. 2005, pp. 1298–300. Pubmed, doi:10.1038/nn1543.
Gazzaley A, Cooney JW, Rissman J, D’Esposito M. Top-down suppression deficit underlies working memory impairment in normal aging. Nat Neurosci. 2005 Oct;8(10):1298–1300.
Published In
Nat Neurosci
DOI
ISSN
1097-6256
Publication Date
October 2005
Volume
8
Issue
10
Start / End Page
1298 / 1300
Location
United States
Related Subject Headings
- Time Factors
- Photic Stimulation
- Oxygen
- Neuropsychological Tests
- Neurology & Neurosurgery
- Middle Aged
- Memory, Short-Term
- Memory Disorders
- Male
- Magnetic Resonance Imaging