New treatment options for lennox-gastaut syndrome
Publication
, Journal Article
Lemmon, ME; Kossoff, EH
Published in: Current Treatment Options in Neurology
August 1, 2013
Opinion statement: Lennox-Gastaut syndrome (LGS) is one of the most difficult epilepsy syndromes to treat, and many children are refractory to standard treatment regimens. Valproic acid, topiramate, and lamotrigine are considered first-line therapies. Newer agents, including clobazam and rufinamide, are promising additions to the current treatment options. The ketogenic diet and vagus nerve stimulation are important adjuncts, with increasing evidence to support their use. Corpus callosotomy should be considered in refractory cases. Finally, focal resective surgery should be considered in patients with lesional disease, although for most patients with LGS this is unlikely to be the case. © 2013 Springer Science+Business Media New York.
Duke Scholars
Published In
Current Treatment Options in Neurology
DOI
EISSN
1534-3138
ISSN
1092-8480
Publication Date
August 1, 2013
Volume
15
Issue
4
Start / End Page
519 / 528
Related Subject Headings
- 3209 Neurosciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Lemmon, M. E., & Kossoff, E. H. (2013). New treatment options for lennox-gastaut syndrome. Current Treatment Options in Neurology, 15(4), 519–528. https://doi.org/10.1007/s11940-013-0223-z
Lemmon, M. E., and E. H. Kossoff. “New treatment options for lennox-gastaut syndrome.” Current Treatment Options in Neurology 15, no. 4 (August 1, 2013): 519–28. https://doi.org/10.1007/s11940-013-0223-z.
Lemmon ME, Kossoff EH. New treatment options for lennox-gastaut syndrome. Current Treatment Options in Neurology. 2013 Aug 1;15(4):519–28.
Lemmon, M. E., and E. H. Kossoff. “New treatment options for lennox-gastaut syndrome.” Current Treatment Options in Neurology, vol. 15, no. 4, Aug. 2013, pp. 519–28. Scopus, doi:10.1007/s11940-013-0223-z.
Lemmon ME, Kossoff EH. New treatment options for lennox-gastaut syndrome. Current Treatment Options in Neurology. 2013 Aug 1;15(4):519–528.
Published In
Current Treatment Options in Neurology
DOI
EISSN
1534-3138
ISSN
1092-8480
Publication Date
August 1, 2013
Volume
15
Issue
4
Start / End Page
519 / 528
Related Subject Headings
- 3209 Neurosciences