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Risperidone use in autism spectrum disorders: a retrospective review of a clinic-referred patient population.

Publication ,  Journal Article
Lemmon, ME; Gregas, M; Jeste, SS
Published in: J Child Neurol
April 2011

Risperidone is widely used in children with autism spectrum disorders for behavioral modification. In this study, the authors aimed to (1) describe a clinic-referred sample of patients with an autism spectrum disorder on risperidone, (2) identify differences between the success and nonsuccess groups, and (3) describe our experience with young children (< age 5 years) on risperidone. Eighty patients were initiated on risperidone. Indications included aggression (66%), impulsivity (14%), and stereotypies (4%). Sixty-six percent met criteria for success at 6 months and 53% at 1 year. Sixty-seven percent of the nonsuccess group reported side effects, compared to 47% of the success group. Weight gain was the most common side effect in both groups, followed by somnolence. Somnolence was the most robust predictor of nonsuccess. In our clinic-referred sample, the short-term success rate of risperidone was more than 50%, and side effects limited its use. Although weight gain was common, somnolence more significantly influenced treatment discontinuation.

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Published In

J Child Neurol

DOI

EISSN

1708-8283

Publication Date

April 2011

Volume

26

Issue

4

Start / End Page

428 / 432

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Sex Factors
  • Risperidone
  • Retrospective Studies
  • Psychiatric Status Rating Scales
  • Predictive Value of Tests
  • Neurology & Neurosurgery
  • Male
  • Logistic Models
  • Humans
 

Citation

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Lemmon, M. E., Gregas, M., & Jeste, S. S. (2011). Risperidone use in autism spectrum disorders: a retrospective review of a clinic-referred patient population. J Child Neurol, 26(4), 428–432. https://doi.org/10.1177/0883073810382143
Lemmon, Monica E., Matt Gregas, and Shafali S. Jeste. “Risperidone use in autism spectrum disorders: a retrospective review of a clinic-referred patient population.J Child Neurol 26, no. 4 (April 2011): 428–32. https://doi.org/10.1177/0883073810382143.
Lemmon, Monica E., et al. “Risperidone use in autism spectrum disorders: a retrospective review of a clinic-referred patient population.J Child Neurol, vol. 26, no. 4, Apr. 2011, pp. 428–32. Pubmed, doi:10.1177/0883073810382143.
Lemmon ME, Gregas M, Jeste SS. Risperidone use in autism spectrum disorders: a retrospective review of a clinic-referred patient population. J Child Neurol. 2011 Apr;26(4):428–432.
Journal cover image

Published In

J Child Neurol

DOI

EISSN

1708-8283

Publication Date

April 2011

Volume

26

Issue

4

Start / End Page

428 / 432

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Sex Factors
  • Risperidone
  • Retrospective Studies
  • Psychiatric Status Rating Scales
  • Predictive Value of Tests
  • Neurology & Neurosurgery
  • Male
  • Logistic Models
  • Humans