Single-amplicon MSH2 A636P mutation testing in Ashkenazi Jewish patients with colorectal cancer: role in presurgical management.
Publication
, Journal Article
Guillem, JG; Glogowski, E; Moore, HG; Nafa, K; Markowitz, AJ; Shia, J; Offit, K; Ellis, NA
Published in: Ann Surg
April 2007
OBJECTIVE: This study summarizes our initial experience with prospective, single-amplicon (mutation-specific) A636P testing in Ashkenazi Jewish patients at risk for Hereditary Nonpolyposis Colorectal Cancer (HNPCC). SUMMARY BACKGROUND DATA: We previously described a founder mutation, MSH2*1906G >C (A636P) that causes HNPCC in 8/1345 (0.59%) of Ashkenazim with colorectal cancer. The mutation was more common in Ashkenazim diagnosed at
Duke Scholars
Published In
Ann Surg
DOI
ISSN
0003-4932
Publication Date
April 2007
Volume
245
Issue
4
Start / End Page
560 / 565
Location
United States
Related Subject Headings
- Surgery
- Prospective Studies
- Pedigree
- MutS Homolog 2 Protein
- Microsatellite Instability
- Male
- Jews
- Humans
- Female
- Europe, Eastern
Citation
APA
Chicago
ICMJE
MLA
NLM
Guillem, J. G., Glogowski, E., Moore, H. G., Nafa, K., Markowitz, A. J., Shia, J., … Ellis, N. A. (2007). Single-amplicon MSH2 A636P mutation testing in Ashkenazi Jewish patients with colorectal cancer: role in presurgical management. Ann Surg, 245(4), 560–565. https://doi.org/10.1097/01.sla.0000252589.26244.d4
Guillem, Jose G., Emily Glogowski, Harvey G. Moore, Khedoudja Nafa, Arnold J. Markowitz, Jinru Shia, Kenneth Offit, and Nathan A. Ellis. “Single-amplicon MSH2 A636P mutation testing in Ashkenazi Jewish patients with colorectal cancer: role in presurgical management.” Ann Surg 245, no. 4 (April 2007): 560–65. https://doi.org/10.1097/01.sla.0000252589.26244.d4.
Guillem JG, Glogowski E, Moore HG, Nafa K, Markowitz AJ, Shia J, et al. Single-amplicon MSH2 A636P mutation testing in Ashkenazi Jewish patients with colorectal cancer: role in presurgical management. Ann Surg. 2007 Apr;245(4):560–5.
Guillem, Jose G., et al. “Single-amplicon MSH2 A636P mutation testing in Ashkenazi Jewish patients with colorectal cancer: role in presurgical management.” Ann Surg, vol. 245, no. 4, Apr. 2007, pp. 560–65. Pubmed, doi:10.1097/01.sla.0000252589.26244.d4.
Guillem JG, Glogowski E, Moore HG, Nafa K, Markowitz AJ, Shia J, Offit K, Ellis NA. Single-amplicon MSH2 A636P mutation testing in Ashkenazi Jewish patients with colorectal cancer: role in presurgical management. Ann Surg. 2007 Apr;245(4):560–565.
Published In
Ann Surg
DOI
ISSN
0003-4932
Publication Date
April 2007
Volume
245
Issue
4
Start / End Page
560 / 565
Location
United States
Related Subject Headings
- Surgery
- Prospective Studies
- Pedigree
- MutS Homolog 2 Protein
- Microsatellite Instability
- Male
- Jews
- Humans
- Female
- Europe, Eastern