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Design and baseline data from the Gratitude Research in Acute Coronary Events (GRACE) study

Publication ,  Journal Article
Huffman, JC; Beale, EE; Beach, SR; Celano, CM; Belcher, AM; Moore, SV; Suarez, L; Gandhi, PU; Motiwala, SR; Gaggin, H; Januzzi, JL
Published in: Contemporary Clinical Trials
September 1, 2015

Background: Positive psychological constructs, especially optimism, have been linked with superior cardiovascular health. However, there has been minimal study of positive constructs in patients with acute coronary syndrome (ACS), despite the prevalence and importance of this condition. Furthermore, few studies have examined multiple positive psychological constructs and multiple cardiac-related outcomes within the same cohort to determine specifically which positive construct may affect a particular cardiac outcome. Materials and methods: The Gratitude Research in Acute Coronary Events (GRACE) study examines the association between optimism/gratitude 2. weeks post-ACS and subsequent clinical outcomes. The primary outcome measure is physical activity at 6. months, measured via accelerometer, and key secondary outcome measures include levels of prognostic biomarkers and rates of nonelective cardiac rehospitalization at 6. months. These relationships will be analyzed using multivariable linear regression, controlling for sociodemographic, medical, and negative psychological factors; associations between baseline positive constructs and subsequent rehospitalizations will be assessed via Cox regression. Results: Overall, 164 participants enrolled and completed the baseline 2-week assessment; the cohort had a mean age of 61.5. +/- 10.5. years and was 84% men; this was the first ACS for 58% of participants. Conclusion: The GRACE study will determine whether optimism and gratitude are prospectively and independently associated with physical activity and other critical outcomes in the 6. months following an ACS. If these constructs are associated with superior outcomes, this may highlight the importance of these constructs as independent prognostic factors post-ACS.

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Published In

Contemporary Clinical Trials

DOI

EISSN

1559-2030

ISSN

1551-7144

Publication Date

September 1, 2015

Volume

44

Start / End Page

11 / 19

Related Subject Headings

  • Public Health
  • General Clinical Medicine
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 11 Medical and Health Sciences
 

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Huffman, J. C., Beale, E. E., Beach, S. R., Celano, C. M., Belcher, A. M., Moore, S. V., … Januzzi, J. L. (2015). Design and baseline data from the Gratitude Research in Acute Coronary Events (GRACE) study. Contemporary Clinical Trials, 44, 11–19. https://doi.org/10.1016/j.cct.2015.07.002
Huffman, J. C., E. E. Beale, S. R. Beach, C. M. Celano, A. M. Belcher, S. V. Moore, L. Suarez, et al. “Design and baseline data from the Gratitude Research in Acute Coronary Events (GRACE) study.” Contemporary Clinical Trials 44 (September 1, 2015): 11–19. https://doi.org/10.1016/j.cct.2015.07.002.
Huffman JC, Beale EE, Beach SR, Celano CM, Belcher AM, Moore SV, et al. Design and baseline data from the Gratitude Research in Acute Coronary Events (GRACE) study. Contemporary Clinical Trials. 2015 Sep 1;44:11–9.
Huffman, J. C., et al. “Design and baseline data from the Gratitude Research in Acute Coronary Events (GRACE) study.” Contemporary Clinical Trials, vol. 44, Sept. 2015, pp. 11–19. Scopus, doi:10.1016/j.cct.2015.07.002.
Huffman JC, Beale EE, Beach SR, Celano CM, Belcher AM, Moore SV, Suarez L, Gandhi PU, Motiwala SR, Gaggin H, Januzzi JL. Design and baseline data from the Gratitude Research in Acute Coronary Events (GRACE) study. Contemporary Clinical Trials. 2015 Sep 1;44:11–19.
Journal cover image

Published In

Contemporary Clinical Trials

DOI

EISSN

1559-2030

ISSN

1551-7144

Publication Date

September 1, 2015

Volume

44

Start / End Page

11 / 19

Related Subject Headings

  • Public Health
  • General Clinical Medicine
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 11 Medical and Health Sciences