Skip to main content
Journal cover image

The N-terminal Pro-BNP investigation of dyspnea in the emergency department (PRIDE) study.

Publication ,  Journal Article
Januzzi, JL; Camargo, CA; Anwaruddin, S; Baggish, AL; Chen, AA; Krauser, DG; Tung, R; Cameron, R; Nagurney, JT; Chae, CU; Lloyd-Jones, DM ...
Published in: Am J Cardiol
April 15, 2005

The utility of aminoterminal pro-brain natriuretic peptide (NT-proBNP) testing in the emergency department to rule out acute congestive heart failure (CHF) and the optimal cutpoints for this use are not established. We conducted a prospective study of 600 patients who presented in the emergency department with dyspnea. The clinical diagnosis of acute CHF was determined by study physicians who were blinded to NT-proBNP results. The primary end point was a comparison of NT-proBNP results with the clinical assessment of the managing physician for identifying acute CHF. The median NT-proBNP level among 209 patients (35%) who had acute CHF was 4,054 versus 131 pg/ml among 390 patients (65%) who did not (p <0.001). NT-proBNP at cutpoints of >450 pg/ml for patients <50 years of age and >900 pg/ml for patients >or=50 years of age were highly sensitive and specific for the diagnosis of acute CHF (p <0.001). An NT-proBNP level <300 pg/ml was optimal for ruling out acute CHF, with a negative predictive value of 99%. Increased NT-proBNP was the strongest independent predictor of a final diagnosis of acute CHF (odds ratio 44, 95% confidence interval 21.0 to 91.0, p <0.0001). NT-proBNP testing alone was superior to clinical judgment alone for diagnosing acute CHF (p = 0.006); NT-proBNP plus clinical judgment was superior to NT-proBNP or clinical judgment alone. NT-proBNP measurement is a valuable addition to standard clinical assessment for the identification and exclusion of acute CHF in the emergency department setting.

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Am J Cardiol

DOI

ISSN

0002-9149

Publication Date

April 15, 2005

Volume

95

Issue

8

Start / End Page

948 / 954

Location

United States

Related Subject Headings

  • Sensitivity and Specificity
  • Prospective Studies
  • Predictive Value of Tests
  • Physical Examination
  • Peptide Fragments
  • Observer Variation
  • Nerve Tissue Proteins
  • Natriuretic Peptide, Brain
  • Middle Aged
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Januzzi, J. L., Camargo, C. A., Anwaruddin, S., Baggish, A. L., Chen, A. A., Krauser, D. G., … Lewandrowski, K. B. (2005). The N-terminal Pro-BNP investigation of dyspnea in the emergency department (PRIDE) study. Am J Cardiol, 95(8), 948–954. https://doi.org/10.1016/j.amjcard.2004.12.032
Januzzi, James L., Carlos A. Camargo, Saif Anwaruddin, Aaron L. Baggish, Annabel A. Chen, Daniel G. Krauser, Roderick Tung, et al. “The N-terminal Pro-BNP investigation of dyspnea in the emergency department (PRIDE) study.Am J Cardiol 95, no. 8 (April 15, 2005): 948–54. https://doi.org/10.1016/j.amjcard.2004.12.032.
Januzzi JL, Camargo CA, Anwaruddin S, Baggish AL, Chen AA, Krauser DG, et al. The N-terminal Pro-BNP investigation of dyspnea in the emergency department (PRIDE) study. Am J Cardiol. 2005 Apr 15;95(8):948–54.
Januzzi, James L., et al. “The N-terminal Pro-BNP investigation of dyspnea in the emergency department (PRIDE) study.Am J Cardiol, vol. 95, no. 8, Apr. 2005, pp. 948–54. Pubmed, doi:10.1016/j.amjcard.2004.12.032.
Januzzi JL, Camargo CA, Anwaruddin S, Baggish AL, Chen AA, Krauser DG, Tung R, Cameron R, Nagurney JT, Chae CU, Lloyd-Jones DM, Brown DF, Foran-Melanson S, Sluss PM, Lee-Lewandrowski E, Lewandrowski KB. The N-terminal Pro-BNP investigation of dyspnea in the emergency department (PRIDE) study. Am J Cardiol. 2005 Apr 15;95(8):948–954.
Journal cover image

Published In

Am J Cardiol

DOI

ISSN

0002-9149

Publication Date

April 15, 2005

Volume

95

Issue

8

Start / End Page

948 / 954

Location

United States

Related Subject Headings

  • Sensitivity and Specificity
  • Prospective Studies
  • Predictive Value of Tests
  • Physical Examination
  • Peptide Fragments
  • Observer Variation
  • Nerve Tissue Proteins
  • Natriuretic Peptide, Brain
  • Middle Aged
  • Male