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Osteoprotegerin concentrations and prognosis in acute ischaemic stroke.

Publication ,  Journal Article
Jensen, JK; Ueland, T; Atar, D; Gullestad, L; Mickley, H; Aukrust, P; Januzzi, JL
Published in: J Intern Med
April 2010

AIM: Concentrations of osteoprotegerin (OPG) have been associated with the presence of vascular and cardiovascular diseases, but the knowledge of this marker in the setting of ischaemic stroke is limited. METHODS AND RESULTS: In 244 patients with acute ischaemic stroke (age: 69 +/- 13 years), samples of OPG were obtained serially from presentation to day 5. Patients with overt ischaemic heart disease and atrial fibrillation were excluded. The patients were followed for 47 months, with all-cause mortality as the sole end-point. Multivariable predictors of OPG values at presentation included haemoglobin (T = -2.82; P = 0.005), creatinine (T = 4.56; P < 0.001), age (T = 9.66; P < 0.001), active smoking (T = 2.25; P = 0.025) and pulse rate (T = 3.23; P = 0.001). At follow-up 72 patients (29%) had died. Patients with OPG < or =2945 pg mL(-1) at baseline had a significantly improved survival rate on univariate analysis (P < 0.0001); other time-points did not add further prognostic information. In multivariate analysis, after adjustment for age, stroke severity, C-reactive protein levels, troponin T levels, heart and renal failure concentrations of OPG independently predicted long-term mortality after stroke (adjusted hazard ratio, 2.3; 95% CI: 1.1 to 4.9; P = 0.024). CONCLUSION: Osteoprotegerin concentrations measured at admission of acute ischaemic stroke are associated with long-term mortality.

Published In

J Intern Med

DOI

EISSN

1365-2796

Publication Date

April 2010

Volume

267

Issue

4

Start / End Page

410 / 417

Location

England

Related Subject Headings

  • Stroke
  • Prognosis
  • Osteoprotegerin
  • Middle Aged
  • Male
  • Linear Models
  • Humans
  • Female
  • Cause of Death
  • Cardiovascular System & Hematology
 

Citation

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Jensen, J. K., Ueland, T., Atar, D., Gullestad, L., Mickley, H., Aukrust, P., & Januzzi, J. L. (2010). Osteoprotegerin concentrations and prognosis in acute ischaemic stroke. J Intern Med, 267(4), 410–417. https://doi.org/10.1111/j.1365-2796.2009.02163.x
Jensen, J. K., T. Ueland, D. Atar, L. Gullestad, H. Mickley, P. Aukrust, and J. L. Januzzi. “Osteoprotegerin concentrations and prognosis in acute ischaemic stroke.J Intern Med 267, no. 4 (April 2010): 410–17. https://doi.org/10.1111/j.1365-2796.2009.02163.x.
Jensen JK, Ueland T, Atar D, Gullestad L, Mickley H, Aukrust P, et al. Osteoprotegerin concentrations and prognosis in acute ischaemic stroke. J Intern Med. 2010 Apr;267(4):410–7.
Jensen, J. K., et al. “Osteoprotegerin concentrations and prognosis in acute ischaemic stroke.J Intern Med, vol. 267, no. 4, Apr. 2010, pp. 410–17. Pubmed, doi:10.1111/j.1365-2796.2009.02163.x.
Jensen JK, Ueland T, Atar D, Gullestad L, Mickley H, Aukrust P, Januzzi JL. Osteoprotegerin concentrations and prognosis in acute ischaemic stroke. J Intern Med. 2010 Apr;267(4):410–417.
Journal cover image

Published In

J Intern Med

DOI

EISSN

1365-2796

Publication Date

April 2010

Volume

267

Issue

4

Start / End Page

410 / 417

Location

England

Related Subject Headings

  • Stroke
  • Prognosis
  • Osteoprotegerin
  • Middle Aged
  • Male
  • Linear Models
  • Humans
  • Female
  • Cause of Death
  • Cardiovascular System & Hematology