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A marriage of enhancement: fibrinolysis and conjunctive therapy.

Publication ,  Journal Article
Welsh, RC; Armstrong, PW
Published in: Thromb Haemost
December 2004

Pharmacologic reperfusion of patients with acute ST segment elevation myocardial infarction is designed to achieve prompt high-quality reperfusion, prevent recurrent ischemia and reinfarction, maintain long-term patency, and to enhance patient survival and quality of life. Because monotherapy with fibrinolytics is by itself unable to achieve all of these objectives, antithrombotic, anti-platelet, and other novel agents are required. We discuss herein the role of unfractionated and enoxaparin, the potential added value of direct thrombin inhibitors, and the importance of aspirin. Despite the promise of glycoprotein IIb/IIIa inhibitors, risks associated with intracranial hemorrhage in the elderly have led to restraint in their application to broad populations. Facilitation of urgent percutaneous coronary intervention with combination reduced-dose fibrinolytic and glycoprotein IIb/IIIa inhibitors remains a promising potential future path. The future is likely to emphasize greater application of the already effective therapies at our disposal and the development of novel anti-platelet and anti-thrombin agents as well as those directed toward inflammation.

Duke Scholars

Published In

Thromb Haemost

DOI

ISSN

0340-6245

Publication Date

December 2004

Volume

92

Issue

6

Start / End Page

1194 / 1200

Location

Germany

Related Subject Headings

  • Thrombolytic Therapy
  • Thrombin
  • Reperfusion Injury
  • Platelet Glycoprotein GPIIb-IIIa Complex
  • Platelet Aggregation Inhibitors
  • Myocardial Infarction
  • Models, Biological
  • Ligands
  • Inflammation
  • Humans
 

Citation

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Welsh, R. C., & Armstrong, P. W. (2004). A marriage of enhancement: fibrinolysis and conjunctive therapy. Thromb Haemost, 92(6), 1194–1200. https://doi.org/10.1160/TH04-02-0072
Welsh, Robert C., and Paul W. Armstrong. “A marriage of enhancement: fibrinolysis and conjunctive therapy.Thromb Haemost 92, no. 6 (December 2004): 1194–1200. https://doi.org/10.1160/TH04-02-0072.
Welsh RC, Armstrong PW. A marriage of enhancement: fibrinolysis and conjunctive therapy. Thromb Haemost. 2004 Dec;92(6):1194–200.
Welsh, Robert C., and Paul W. Armstrong. “A marriage of enhancement: fibrinolysis and conjunctive therapy.Thromb Haemost, vol. 92, no. 6, Dec. 2004, pp. 1194–200. Pubmed, doi:10.1160/TH04-02-0072.
Welsh RC, Armstrong PW. A marriage of enhancement: fibrinolysis and conjunctive therapy. Thromb Haemost. 2004 Dec;92(6):1194–1200.
Journal cover image

Published In

Thromb Haemost

DOI

ISSN

0340-6245

Publication Date

December 2004

Volume

92

Issue

6

Start / End Page

1194 / 1200

Location

Germany

Related Subject Headings

  • Thrombolytic Therapy
  • Thrombin
  • Reperfusion Injury
  • Platelet Glycoprotein GPIIb-IIIa Complex
  • Platelet Aggregation Inhibitors
  • Myocardial Infarction
  • Models, Biological
  • Ligands
  • Inflammation
  • Humans