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Country specific cost comparisons from multinational clinical trials using empirical Bayesian shrinkage estimation: the Canadian ASSENT-3 economic analysis.

Publication ,  Journal Article
Willan, AR; Pinto, EM; O'Brien, BJ; Kaul, P; Goeree, R; Lynd, L; Armstrong, PW
Published in: Health Econ
April 2005

The growing number of multinational clinical trials in which patient-level health care resource data are collected have raised the issue of which is the best approach for making inference for individual countries with respect to the between-treatment difference in mean cost. We describe and discuss the relative merits of three approaches. The first uses the random effects pooled estimate from all countries to estimate the difference for any particular country. The second approach estimates the difference using only the data from the specific country in question. Using empirical Bayes estimation a third approach estimates the country-specific difference using a variance-weighted linear sum of the estimates provided by the other two approaches. The approaches are illustrated and compared using the data from the ASSENT-3 trial.

Duke Scholars

Published In

Health Econ

DOI

ISSN

1057-9230

Publication Date

April 2005

Volume

14

Issue

4

Start / End Page

327 / 338

Location

England

Related Subject Headings

  • Randomized Controlled Trials as Topic
  • Myocardial Infarction
  • Multicenter Studies as Topic
  • International Cooperation
  • Immunoglobulin Fab Fragments
  • Humans
  • Heparin
  • Health Policy & Services
  • Health Care Costs
  • Enoxaparin
 

Citation

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Chicago
ICMJE
MLA
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Willan, A. R., Pinto, E. M., O’Brien, B. J., Kaul, P., Goeree, R., Lynd, L., & Armstrong, P. W. (2005). Country specific cost comparisons from multinational clinical trials using empirical Bayesian shrinkage estimation: the Canadian ASSENT-3 economic analysis. Health Econ, 14(4), 327–338. https://doi.org/10.1002/hec.969
Willan, Andrew R., Eleanor M. Pinto, Bernie J. O’Brien, Padma Kaul, Ron Goeree, Larry Lynd, and Paul W. Armstrong. “Country specific cost comparisons from multinational clinical trials using empirical Bayesian shrinkage estimation: the Canadian ASSENT-3 economic analysis.Health Econ 14, no. 4 (April 2005): 327–38. https://doi.org/10.1002/hec.969.
Willan AR, Pinto EM, O’Brien BJ, Kaul P, Goeree R, Lynd L, et al. Country specific cost comparisons from multinational clinical trials using empirical Bayesian shrinkage estimation: the Canadian ASSENT-3 economic analysis. Health Econ. 2005 Apr;14(4):327–38.
Willan, Andrew R., et al. “Country specific cost comparisons from multinational clinical trials using empirical Bayesian shrinkage estimation: the Canadian ASSENT-3 economic analysis.Health Econ, vol. 14, no. 4, Apr. 2005, pp. 327–38. Pubmed, doi:10.1002/hec.969.
Willan AR, Pinto EM, O’Brien BJ, Kaul P, Goeree R, Lynd L, Armstrong PW. Country specific cost comparisons from multinational clinical trials using empirical Bayesian shrinkage estimation: the Canadian ASSENT-3 economic analysis. Health Econ. 2005 Apr;14(4):327–338.
Journal cover image

Published In

Health Econ

DOI

ISSN

1057-9230

Publication Date

April 2005

Volume

14

Issue

4

Start / End Page

327 / 338

Location

England

Related Subject Headings

  • Randomized Controlled Trials as Topic
  • Myocardial Infarction
  • Multicenter Studies as Topic
  • International Cooperation
  • Immunoglobulin Fab Fragments
  • Humans
  • Heparin
  • Health Policy & Services
  • Health Care Costs
  • Enoxaparin