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Physiological effects of synthetic atrial natriuretic factor in normal conscious dogs.

Publication ,  Journal Article
Moe, GW; Forster, C; de Bold, AJ; Armstrong, PW
Published in: Clin Invest Med
December 1988

The objective of this study was to examine the integrative physiologic effects of atrial natriuretic factor (ANF). Synthetic 99-126 ANF was administered to 6 normal conscious dogs as two consecutive infusions (0.02 and 0.1 microgram/kg/min respectively) each over 30 min: each infusion was preceded by a priming dose of 1 microgram/kg. With the first infusion, mean arterial pressure declined from 113 +/- 2 to 103 +/- 4 mmHg, pulmonary capillary wedge pressure declined from 9.6 +/- 0.5 to 7.2 +/- 0.7 mmHg and right atrial pressure declined from 9.8 +/- 0.4 to 8.0 +/- 0.7 mmHg (all p less than 0.05). No change in heart rate was seen. Despite very high plasma ANF concentrations, no further decline in arterial or central filling pressures were seen in the second infusion. In contrast, cardiac output declined progressively from 3.8 +/- 0.2 to 2.8 +/- 0.21/min (p less than 0.01) by the end of second infusion. Plasma renin activity declined from 2.2 +/- 0.7 to 0.9 +/- 0.3 ng/ml/hr (p less than 0.05) while plasma norepinephrine remained unchanged. Urine output and sodium excretion increased in a dose dependent manner. The diverse time course of the hemodynamic, renal and neuroendocrine effects suggests these effects of ANF are mediated by different mechanisms. Furthermore, the failure of heart rate and plasma norepinephrine to increase despite a significant decline in blood pressure and cardiac output suggests ANF may have a depressant effect on the sympathetic nervous system.

Duke Scholars

Published In

Clin Invest Med

ISSN

0147-958X

Publication Date

December 1988

Volume

11

Issue

6

Start / End Page

417 / 424

Location

Canada

Related Subject Headings

  • Renin
  • Norepinephrine
  • Natriuresis
  • Kidney
  • Hemodynamics
  • General Clinical Medicine
  • Dogs
  • Atrial Natriuretic Factor
  • Animals
  • 11 Medical and Health Sciences
 

Citation

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MLA
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Moe, G. W., Forster, C., de Bold, A. J., & Armstrong, P. W. (1988). Physiological effects of synthetic atrial natriuretic factor in normal conscious dogs. Clin Invest Med, 11(6), 417–424.
Moe, G. W., C. Forster, A. J. de Bold, and P. W. Armstrong. “Physiological effects of synthetic atrial natriuretic factor in normal conscious dogs.Clin Invest Med 11, no. 6 (December 1988): 417–24.
Moe GW, Forster C, de Bold AJ, Armstrong PW. Physiological effects of synthetic atrial natriuretic factor in normal conscious dogs. Clin Invest Med. 1988 Dec;11(6):417–24.
Moe, G. W., et al. “Physiological effects of synthetic atrial natriuretic factor in normal conscious dogs.Clin Invest Med, vol. 11, no. 6, Dec. 1988, pp. 417–24.
Moe GW, Forster C, de Bold AJ, Armstrong PW. Physiological effects of synthetic atrial natriuretic factor in normal conscious dogs. Clin Invest Med. 1988 Dec;11(6):417–424.

Published In

Clin Invest Med

ISSN

0147-958X

Publication Date

December 1988

Volume

11

Issue

6

Start / End Page

417 / 424

Location

Canada

Related Subject Headings

  • Renin
  • Norepinephrine
  • Natriuresis
  • Kidney
  • Hemodynamics
  • General Clinical Medicine
  • Dogs
  • Atrial Natriuretic Factor
  • Animals
  • 11 Medical and Health Sciences