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Nitroglycerin ointment in acute myocardial infarction.

Publication ,  Journal Article
Armstrong, PW; Mathew, MT; Boroomand, K; Parker, JO
Published in: Am J Cardiol
October 1976

The hemodynamic effects of nitroglycerin ointment were studied in 22 patients with acute myocardial infarction. Control measurements were obtained and observations were made over the ensuing 240 minutes. There was no change in heart rate, cardiac index or stroke index. Ninety minutes after application of the ointment, peak decrements were evident in mean arterial pressure (from 100 to 88 mm Hg) (P less than 0.001), pulmonary capillary wedge pressure (from 19 to 13 mm Hg) (P less than 0.001), right atrial pressure (from 8 to 5 mm Hg) (P less than 0.001) and heart X systolic blood pressure (from 1,155 to 1,044 mm Hg/min X 10(-1) (P less than 0.02); significant changes were still present at 240 minutes. Total peripheral resistance decreased maximally from 19.8 to 17.2 units (P less than 0.02); the transmyocardial gradient (arterial diastolic -- pulmonary capillary wedge pressure) did not decrease during the study. These data indicate that nitroglycerin ointment improves cardiac performance in patients with acute myocardial infarction while reducing the determinants of myocardial oxygen consumption and preserving the transmyocardial gradient for coronary blood flow.

Duke Scholars

Published In

Am J Cardiol

DOI

ISSN

0002-9149

Publication Date

October 1976

Volume

38

Issue

4

Start / End Page

474 / 478

Location

United States

Related Subject Headings

  • Vascular Resistance
  • Time Factors
  • Ointments
  • Nitroglycerin
  • Myocardial Infarction
  • Middle Aged
  • Male
  • Infusions, Parenteral
  • Hypotension
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Armstrong, P. W., Mathew, M. T., Boroomand, K., & Parker, J. O. (1976). Nitroglycerin ointment in acute myocardial infarction. Am J Cardiol, 38(4), 474–478. https://doi.org/10.1016/0002-9149(76)90466-5
Armstrong, P. W., M. T. Mathew, K. Boroomand, and J. O. Parker. “Nitroglycerin ointment in acute myocardial infarction.Am J Cardiol 38, no. 4 (October 1976): 474–78. https://doi.org/10.1016/0002-9149(76)90466-5.
Armstrong PW, Mathew MT, Boroomand K, Parker JO. Nitroglycerin ointment in acute myocardial infarction. Am J Cardiol. 1976 Oct;38(4):474–8.
Armstrong, P. W., et al. “Nitroglycerin ointment in acute myocardial infarction.Am J Cardiol, vol. 38, no. 4, Oct. 1976, pp. 474–78. Pubmed, doi:10.1016/0002-9149(76)90466-5.
Armstrong PW, Mathew MT, Boroomand K, Parker JO. Nitroglycerin ointment in acute myocardial infarction. Am J Cardiol. 1976 Oct;38(4):474–478.
Journal cover image

Published In

Am J Cardiol

DOI

ISSN

0002-9149

Publication Date

October 1976

Volume

38

Issue

4

Start / End Page

474 / 478

Location

United States

Related Subject Headings

  • Vascular Resistance
  • Time Factors
  • Ointments
  • Nitroglycerin
  • Myocardial Infarction
  • Middle Aged
  • Male
  • Infusions, Parenteral
  • Hypotension
  • Humans