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Incontinence and gait disturbance after intraventricular extension of intracerebral hemorrhage.

Publication ,  Journal Article
Woo, D; Kruger, AJ; Sekar, P; Haverbusch, M; Osborne, J; Moomaw, CJ; Martini, S; Hosseini, SM; Ferioli, S; Worrall, BB; Elkind, MSV; Sung, G ...
Published in: Neurology
March 8, 2016

OBJECTIVE: We tested the hypothesis that intraventricular hemorrhage (IVH) is associated with incontinence and gait disturbance among survivors of intracerebral hemorrhage (ICH) at 3-month follow-ups. METHODS: The Genetic and Environmental Risk Factors for Hemorrhagic Stroke study was used as the discovery set. The Ethnic/Racial Variations of Intracerebral Hemorrhage study served as a replication set. Both studies performed prospective hot-pursuit recruitment of ICH cases with 3-month follow-up. Multivariable logistic regression analyses were computed to identify risk factors for incontinence and gait dysmobility at 3 months after ICH. RESULTS: The study population consisted of 307 ICH cases in the discovery set and 1,374 cases in the replication set. In the discovery set, we found that increasing IVH volume was associated with incontinence (odds ratio [OR] 1.50; 95% confidence interval [CI] 1.10-2.06) and dysmobility (OR 1.58; 95% CI 1.17-2.15) after controlling for ICH location, initial ICH volume, age, baseline modified Rankin Scale score, sex, and admission Glasgow Coma Scale score. In the replication set, increasing IVH volume was also associated with both incontinence (OR 1.42; 95% CI 1.27-1.60) and dysmobility (OR 1.40; 95% CI 1.24-1.57) after controlling for the same variables. CONCLUSION: ICH subjects with IVH extension are at an increased risk for developing incontinence and dysmobility after controlling for factors associated with severity and disability. This finding suggests a potential target to prevent or treat long-term disability after ICH with IVH.

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Published In

Neurology

DOI

EISSN

1526-632X

Publication Date

March 8, 2016

Volume

86

Issue

10

Start / End Page

905 / 911

Location

United States

Related Subject Headings

  • Urinary Incontinence
  • Treatment Outcome
  • Prospective Studies
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Humans
  • Gait Disorders, Neurologic
  • Follow-Up Studies
  • Female
 

Citation

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Woo, D., Kruger, A. J., Sekar, P., Haverbusch, M., Osborne, J., Moomaw, C. J., … Flaherty, M. L. (2016). Incontinence and gait disturbance after intraventricular extension of intracerebral hemorrhage. Neurology, 86(10), 905–911. https://doi.org/10.1212/WNL.0000000000002449
Woo, Daniel, Andrew J. Kruger, Padmini Sekar, Mary Haverbusch, Jennifer Osborne, Charles J. Moomaw, Sharyl Martini, et al. “Incontinence and gait disturbance after intraventricular extension of intracerebral hemorrhage.Neurology 86, no. 10 (March 8, 2016): 905–11. https://doi.org/10.1212/WNL.0000000000002449.
Woo D, Kruger AJ, Sekar P, Haverbusch M, Osborne J, Moomaw CJ, et al. Incontinence and gait disturbance after intraventricular extension of intracerebral hemorrhage. Neurology. 2016 Mar 8;86(10):905–11.
Woo, Daniel, et al. “Incontinence and gait disturbance after intraventricular extension of intracerebral hemorrhage.Neurology, vol. 86, no. 10, Mar. 2016, pp. 905–11. Pubmed, doi:10.1212/WNL.0000000000002449.
Woo D, Kruger AJ, Sekar P, Haverbusch M, Osborne J, Moomaw CJ, Martini S, Hosseini SM, Ferioli S, Worrall BB, Elkind MSV, Sung G, James ML, Testai FD, Langefeld CD, Broderick JP, Koch S, Flaherty ML. Incontinence and gait disturbance after intraventricular extension of intracerebral hemorrhage. Neurology. 2016 Mar 8;86(10):905–911.

Published In

Neurology

DOI

EISSN

1526-632X

Publication Date

March 8, 2016

Volume

86

Issue

10

Start / End Page

905 / 911

Location

United States

Related Subject Headings

  • Urinary Incontinence
  • Treatment Outcome
  • Prospective Studies
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Humans
  • Gait Disorders, Neurologic
  • Follow-Up Studies
  • Female