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Sialylated Milk Oligosaccharides Promote Microbiota-Dependent Growth in Models of Infant Undernutrition.

Publication ,  Journal Article
Charbonneau, MR; O'Donnell, D; Blanton, LV; Totten, SM; Davis, JCC; Barratt, MJ; Cheng, J; Guruge, J; Talcott, M; Bain, JR; Muehlbauer, MJ ...
Published in: Cell
February 25, 2016

Identifying interventions that more effectively promote healthy growth of children with undernutrition is a pressing global health goal. Analysis of human milk oligosaccharides (HMOs) from 6-month-postpartum mothers in two Malawian birth cohorts revealed that sialylated HMOs are significantly less abundant in those with severely stunted infants. To explore this association, we colonized young germ-free mice with a consortium of bacterial strains cultured from the fecal microbiota of a 6-month-old stunted Malawian infant and fed recipient animals a prototypic Malawian diet with or without purified sialylated bovine milk oligosaccharides (S-BMO). S-BMO produced a microbiota-dependent augmentation of lean body mass gain, changed bone morphology, and altered liver, muscle, and brain metabolism in ways indicative of a greater ability to utilize nutrients for anabolism. These effects were also documented in gnotobiotic piglets using the same consortium and Malawian diet. These preclinical models indicate a causal, microbiota-dependent relationship between S-BMO and growth promotion.

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Published In

Cell

DOI

EISSN

1097-4172

Publication Date

February 25, 2016

Volume

164

Issue

5

Start / End Page

859 / 871

Location

United States

Related Subject Headings

  • Oligosaccharides
  • Milk, Human
  • Milk
  • Microbiota
  • Mice, Inbred C57BL
  • Mice
  • Metabolomics
  • Malnutrition
  • Male
  • Malawi
 

Citation

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Charbonneau, M. R., O’Donnell, D., Blanton, L. V., Totten, S. M., Davis, J. C. C., Barratt, M. J., … Gordon, J. I. (2016). Sialylated Milk Oligosaccharides Promote Microbiota-Dependent Growth in Models of Infant Undernutrition. Cell, 164(5), 859–871. https://doi.org/10.1016/j.cell.2016.01.024
Charbonneau, Mark R., David O’Donnell, Laura V. Blanton, Sarah M. Totten, Jasmine C. C. Davis, Michael J. Barratt, Jiye Cheng, et al. “Sialylated Milk Oligosaccharides Promote Microbiota-Dependent Growth in Models of Infant Undernutrition.Cell 164, no. 5 (February 25, 2016): 859–71. https://doi.org/10.1016/j.cell.2016.01.024.
Charbonneau MR, O’Donnell D, Blanton LV, Totten SM, Davis JCC, Barratt MJ, et al. Sialylated Milk Oligosaccharides Promote Microbiota-Dependent Growth in Models of Infant Undernutrition. Cell. 2016 Feb 25;164(5):859–71.
Charbonneau, Mark R., et al. “Sialylated Milk Oligosaccharides Promote Microbiota-Dependent Growth in Models of Infant Undernutrition.Cell, vol. 164, no. 5, Feb. 2016, pp. 859–71. Pubmed, doi:10.1016/j.cell.2016.01.024.
Charbonneau MR, O’Donnell D, Blanton LV, Totten SM, Davis JCC, Barratt MJ, Cheng J, Guruge J, Talcott M, Bain JR, Muehlbauer MJ, Ilkayeva O, Wu C, Struckmeyer T, Barile D, Mangani C, Jorgensen J, Fan Y-M, Maleta K, Dewey KG, Ashorn P, Newgard CB, Lebrilla C, Mills DA, Gordon JI. Sialylated Milk Oligosaccharides Promote Microbiota-Dependent Growth in Models of Infant Undernutrition. Cell. 2016 Feb 25;164(5):859–871.
Journal cover image

Published In

Cell

DOI

EISSN

1097-4172

Publication Date

February 25, 2016

Volume

164

Issue

5

Start / End Page

859 / 871

Location

United States

Related Subject Headings

  • Oligosaccharides
  • Milk, Human
  • Milk
  • Microbiota
  • Mice, Inbred C57BL
  • Mice
  • Metabolomics
  • Malnutrition
  • Male
  • Malawi