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Chronic exposure to air pollution particles increases the risk of obesity and metabolic syndrome: findings from a natural experiment in Beijing.

Publication ,  Journal Article
Wei, Y; Zhang, JJ; Li, Z; Gow, A; Chung, KF; Hu, M; Sun, Z; Zeng, L; Zhu, T; Jia, G; Li, X; Duarte, M; Tang, X
Published in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
June 2016

Epidemiologic evidence suggests that air pollution is a risk factor for childhood obesity. Limited experimental data have shown that early-life exposure to ambient particles either increases susceptibility to diet-induced weight gain in adulthood or increases insulin resistance, adiposity, and inflammation. However, no data have directly supported a link between air pollution and non-diet-induced weight increases. In a rodent model, we found that breathing Beijing's highly polluted air resulted in weight gain and cardiorespiratory and metabolic dysfunction. Compared to those exposed to filtered air, pregnant rats exposed to unfiltered Beijing air were significantly heavier at the end of pregnancy. At 8 wk old, the offspring prenatally and postnatally exposed to unfiltered air were significantly heavier than those exposed to filtered air. In both rat dams and their offspring, after continuous exposure to unfiltered air we observed pronounced histologic evidence for both perivascular and peribronchial inflammation in the lungs, increased tissue and systemic oxidative stress, dyslipidemia, and an enhanced proinflammatory status of epididymal fat. Results suggest that TLR2/4-dependent inflammatory activation and lipid oxidation in the lung can spill over systemically, leading to metabolic dysfunction and weight gain.-Wei, Y., Zhang, J., Li, Z., Gow, A., Chung, K. F., Hu, M., Sun, Z., Zeng, L., Zhu, T., Jia, G., Li, X., Duarte, M., Tang, X. Chronic exposure to air pollution particles increases the risk of obesity and metabolic syndrome: findings from a natural experiment in Beijing.

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Published In

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

DOI

EISSN

1530-6860

ISSN

0892-6638

Publication Date

June 2016

Volume

30

Issue

6

Start / End Page

2115 / 2122

Related Subject Headings

  • Time Factors
  • Rats, Sprague-Dawley
  • Rats
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Particulate Matter
  • Obesity
  • Metabolic Syndrome
  • Male
  • Female
 

Citation

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Wei, Y., Zhang, J. J., Li, Z., Gow, A., Chung, K. F., Hu, M., … Tang, X. (2016). Chronic exposure to air pollution particles increases the risk of obesity and metabolic syndrome: findings from a natural experiment in Beijing. FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology, 30(6), 2115–2122. https://doi.org/10.1096/fj.201500142
Wei, Yongjie, Junfeng Jim Zhang, Zhigang Li, Andrew Gow, Kian Fan Chung, Min Hu, Zhongsheng Sun, et al. “Chronic exposure to air pollution particles increases the risk of obesity and metabolic syndrome: findings from a natural experiment in Beijing.FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology 30, no. 6 (June 2016): 2115–22. https://doi.org/10.1096/fj.201500142.
Wei Y, Zhang JJ, Li Z, Gow A, Chung KF, Hu M, et al. Chronic exposure to air pollution particles increases the risk of obesity and metabolic syndrome: findings from a natural experiment in Beijing. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2016 Jun;30(6):2115–22.
Wei, Yongjie, et al. “Chronic exposure to air pollution particles increases the risk of obesity and metabolic syndrome: findings from a natural experiment in Beijing.FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology, vol. 30, no. 6, June 2016, pp. 2115–22. Epmc, doi:10.1096/fj.201500142.
Wei Y, Zhang JJ, Li Z, Gow A, Chung KF, Hu M, Sun Z, Zeng L, Zhu T, Jia G, Li X, Duarte M, Tang X. Chronic exposure to air pollution particles increases the risk of obesity and metabolic syndrome: findings from a natural experiment in Beijing. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2016 Jun;30(6):2115–2122.

Published In

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

DOI

EISSN

1530-6860

ISSN

0892-6638

Publication Date

June 2016

Volume

30

Issue

6

Start / End Page

2115 / 2122

Related Subject Headings

  • Time Factors
  • Rats, Sprague-Dawley
  • Rats
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Particulate Matter
  • Obesity
  • Metabolic Syndrome
  • Male
  • Female