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Improved quality of life following total pancreatectomy and auto-islet transplantation for chronic pancreatitis.

Publication ,  Journal Article
Walsh, RM; Saavedra, JRA; Lentz, G; Guerron, AD; Scheman, J; Stevens, T; Trucco, M; Bottino, R; Hatipoglu, B
Published in: Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
August 2012

Total pancreatectomy (TP) with auto-islet transplant (AIT) is an extreme treatment for chronic pancreatitis, and we reviewed our experience to assess the impact on quality of life (QOL).A prospective cohort study from 2007 through 2010 with pre- and postoperative assessments of the Depression Anxiety Stress Scale, Pain Disability Index, and visual analogue pain scale was performed.Twenty patients underwent TP-AIT with a median follow-up of 12 months (6.75-24 months). All patients reported moderate (45 %) to severe (55 %) pain prior to surgery. TP-AIT resulted in significant decreases in abdominal pain (p < 0.001), 80 % reporting no or mild pain. Despite pain improvement, only 30 % discontinued narcotics. Improvements in all PDI QOL domains improved from 79 to 90 % (p = 0.002), with greatest improvements seen in those without prior pancreatic surgery, younger patients, and in those with higher levels of preoperative pain. Patients were less affected by depression and anxiety prior to surgery, but 60 and 70 % did show improvement in depression and anxiety, respectively (p = 0.033). Sixteen patients (80 %) required exogenous insulin at last follow-up (mean total dose of insulin 11.6 U/day).TP-AIT significantly improves pain and QOL measures in appropriately selected patients with CP.

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Published In

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

DOI

EISSN

1873-4626

ISSN

1091-255X

Publication Date

August 2012

Volume

16

Issue

8

Start / End Page

1469 / 1477

Related Subject Headings

  • Treatment Outcome
  • Transplantation, Autologous
  • Surgery
  • Quality of Life
  • Prospective Studies
  • Postoperative Complications
  • Pancreatitis, Chronic
  • Pancreaticoduodenectomy
  • Pancreatectomy
  • Middle Aged
 

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Walsh, R. M., Saavedra, J. R. A., Lentz, G., Guerron, A. D., Scheman, J., Stevens, T., … Hatipoglu, B. (2012). Improved quality of life following total pancreatectomy and auto-islet transplantation for chronic pancreatitis. Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract, 16(8), 1469–1477. https://doi.org/10.1007/s11605-012-1914-6
Walsh, R. M., JR Aguilar Saavedra, G. Lentz, A. D. Guerron, J. Scheman, T. Stevens, M. Trucco, R. Bottino, and B. Hatipoglu. “Improved quality of life following total pancreatectomy and auto-islet transplantation for chronic pancreatitis.Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract 16, no. 8 (August 2012): 1469–77. https://doi.org/10.1007/s11605-012-1914-6.
Walsh RM, Saavedra JRA, Lentz G, Guerron AD, Scheman J, Stevens T, et al. Improved quality of life following total pancreatectomy and auto-islet transplantation for chronic pancreatitis. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. 2012 Aug;16(8):1469–77.
Walsh, R. M., et al. “Improved quality of life following total pancreatectomy and auto-islet transplantation for chronic pancreatitis.Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract, vol. 16, no. 8, Aug. 2012, pp. 1469–77. Epmc, doi:10.1007/s11605-012-1914-6.
Walsh RM, Saavedra JRA, Lentz G, Guerron AD, Scheman J, Stevens T, Trucco M, Bottino R, Hatipoglu B. Improved quality of life following total pancreatectomy and auto-islet transplantation for chronic pancreatitis. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. 2012 Aug;16(8):1469–1477.
Journal cover image

Published In

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

DOI

EISSN

1873-4626

ISSN

1091-255X

Publication Date

August 2012

Volume

16

Issue

8

Start / End Page

1469 / 1477

Related Subject Headings

  • Treatment Outcome
  • Transplantation, Autologous
  • Surgery
  • Quality of Life
  • Prospective Studies
  • Postoperative Complications
  • Pancreatitis, Chronic
  • Pancreaticoduodenectomy
  • Pancreatectomy
  • Middle Aged