Comparison of the effects of human adipose and bone marrow mesenchymal stem cells on T lymphocytes
Publication
, Journal Article
Zhu, XS; He, BX; Zhou, XN; Ren, J
Published in: Cell Biology International
2013
Mesenchymal stem cells (MSCs) are multipotent cells that can be derived either from the bone marrow (bMSCs) or adipose tissue (aMSCs). We have compared the immune regulatory properties of cells derived from bone marrow and adipose tissue to provide a theoretical basis for the choice of stem cell source for transplantation. The phenotypes of bMSCs and aMSCs are similar, differing only in the expression of CD106. aMSCs proliferate faster than bMSCs, but aMSCs suppressed T-lymphocyte proliferation and activation more poorly than bMSCs. Thus cell origin and abundance are important factors in determining the suitability of MSCs for transplantation. Adipose tissue offers a more promising source of cells for such an application.
Duke Scholars
Published In
Cell Biology International
DOI
ISSN
1065-6995
Publication Date
2013
Volume
37
Start / End Page
11 / 18
Related Subject Headings
- Biochemistry & Molecular Biology
- 0601 Biochemistry and Cell Biology
Citation
APA
Chicago
ICMJE
MLA
NLM
Zhu, X. S., He, B. X., Zhou, X. N., & Ren, J. (2013). Comparison of the effects of human adipose and bone marrow mesenchymal stem cells on T lymphocytes. Cell Biology International, 37, 11–18. https://doi.org/10.1002/cbin.10002
Zhu, X. S., B. X. He, X. N. Zhou, and J. Ren. “Comparison of the effects of human adipose and bone marrow mesenchymal stem cells on T lymphocytes.” Cell Biology International 37 (2013): 11–18. https://doi.org/10.1002/cbin.10002.
Zhu XS, He BX, Zhou XN, Ren J. Comparison of the effects of human adipose and bone marrow mesenchymal stem cells on T lymphocytes. Cell Biology International. 2013;37:11–8.
Zhu, X. S., et al. “Comparison of the effects of human adipose and bone marrow mesenchymal stem cells on T lymphocytes.” Cell Biology International, vol. 37, 2013, pp. 11–18. Manual, doi:10.1002/cbin.10002.
Zhu XS, He BX, Zhou XN, Ren J. Comparison of the effects of human adipose and bone marrow mesenchymal stem cells on T lymphocytes. Cell Biology International. 2013;37:11–18.
Published In
Cell Biology International
DOI
ISSN
1065-6995
Publication Date
2013
Volume
37
Start / End Page
11 / 18
Related Subject Headings
- Biochemistry & Molecular Biology
- 0601 Biochemistry and Cell Biology