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Association of Plasma Small-Molecule Intermediate Metabolites With Age and Body Mass Index Across Six Diverse Study Populations.

Publication ,  Journal Article
Kraus, WE; Pieper, CF; Huffman, KM; Thompson, DK; Kraus, VB; Morey, MC; Cohen, HJ; Ravussin, E; Redman, LM; Bain, JR; Stevens, RD; Newgard, CB
Published in: J Gerontol A Biol Sci Med Sci
November 2016

BACKGROUND: Older age and obesity are associated with metabolic dysregulation; the mechanism by which these factors impact metabolism across the lifespan is important, but relatively unknown. We evaluated a panel of amino acids (AAs) and acylcarnitines (ACs) to identify effects of age and adiposity (body mass index) on circulating small-molecule metabolites in a meta-analysis of six diverse study populations. METHODS: Targeted metabolic profiling was performed in six independent studies, representing 739 subjects with a broad range of age, body mass index, health states, and ethnic origin. Principal components analysis was performed on log-normalized values for AAs and ACs separately, generating one AC factor and two AA factors for each study. A common AC factor consisted primarily of acetylcarnitine, medium-chain AC, and several long-chain AC. AA Factor 1 consisted primarily of large neutral AAs. Glycine was its own factor. RESULTS: Metabolic profiling and factor analysis identified clusters of related metabolites of lipid and AA metabolism that were consistently associated with age and body mass in a series of studies with a broad range of age, body mass index, and health status. An inverse association of glycine with body mass index and male gender supports its role as a marker of favorable metabolic health. CONCLUSIONS: An important focus of future investigations should be to determine whether these clusters of metabolic intermediates are possible early predictors of health outcomes associated with body mass; are involved with accelerated aging; are involved in the causative pathway of aging; and how modification of these metabolic pathways impact the biology of aging.

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Published In

J Gerontol A Biol Sci Med Sci

DOI

EISSN

1758-535X

Publication Date

November 2016

Volume

71

Issue

11

Start / End Page

1507 / 1513

Location

United States

Related Subject Headings

  • Plasma
  • Obesity
  • Metabolomics
  • Male
  • Humans
  • Gerontology
  • Female
  • Carnitine
  • Body Mass Index
  • Amino Acids
 

Citation

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MLA
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Kraus, W. E., Pieper, C. F., Huffman, K. M., Thompson, D. K., Kraus, V. B., Morey, M. C., … Newgard, C. B. (2016). Association of Plasma Small-Molecule Intermediate Metabolites With Age and Body Mass Index Across Six Diverse Study Populations. J Gerontol A Biol Sci Med Sci, 71(11), 1507–1513. https://doi.org/10.1093/gerona/glw031
Kraus, William E., Carl F. Pieper, Kim M. Huffman, Dana K. Thompson, Virginia B. Kraus, Miriam C. Morey, Harvey J. Cohen, et al. “Association of Plasma Small-Molecule Intermediate Metabolites With Age and Body Mass Index Across Six Diverse Study Populations.J Gerontol A Biol Sci Med Sci 71, no. 11 (November 2016): 1507–13. https://doi.org/10.1093/gerona/glw031.
Kraus WE, Pieper CF, Huffman KM, Thompson DK, Kraus VB, Morey MC, et al. Association of Plasma Small-Molecule Intermediate Metabolites With Age and Body Mass Index Across Six Diverse Study Populations. J Gerontol A Biol Sci Med Sci. 2016 Nov;71(11):1507–13.
Kraus, William E., et al. “Association of Plasma Small-Molecule Intermediate Metabolites With Age and Body Mass Index Across Six Diverse Study Populations.J Gerontol A Biol Sci Med Sci, vol. 71, no. 11, Nov. 2016, pp. 1507–13. Pubmed, doi:10.1093/gerona/glw031.
Kraus WE, Pieper CF, Huffman KM, Thompson DK, Kraus VB, Morey MC, Cohen HJ, Ravussin E, Redman LM, Bain JR, Stevens RD, Newgard CB. Association of Plasma Small-Molecule Intermediate Metabolites With Age and Body Mass Index Across Six Diverse Study Populations. J Gerontol A Biol Sci Med Sci. 2016 Nov;71(11):1507–1513.
Journal cover image

Published In

J Gerontol A Biol Sci Med Sci

DOI

EISSN

1758-535X

Publication Date

November 2016

Volume

71

Issue

11

Start / End Page

1507 / 1513

Location

United States

Related Subject Headings

  • Plasma
  • Obesity
  • Metabolomics
  • Male
  • Humans
  • Gerontology
  • Female
  • Carnitine
  • Body Mass Index
  • Amino Acids