Regulation of Gap Junction Dynamics by UNC-44/ankyrin and UNC-33/CRMP through VAB-8 in C. elegans Neurons.
Publication
, Journal Article
Meng, L; Chen, C-H; Yan, D
Published in: PLoS Genet
March 2016
Gap junctions are present in both vertebrates and invertebrates from nematodes to mammals. Although the importance of gap junctions has been documented in many biological processes, the molecular mechanisms underlying gap junction dynamics remain unclear. Here, using the C. elegans PLM neurons as a model, we show that UNC-44/ankyrin acts upstream of UNC-33/CRMP in regulation of a potential kinesin VAB-8 to control gap junction dynamics, and loss-of-function in the UNC-44/UNC-33/VAB-8 pathway suppresses the turnover of gap junction channels. Therefore, we first show a signal pathway including ankyrin, CRMP, and kinesin in regulating gap junctions.
Duke Scholars
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Published In
PLoS Genet
DOI
EISSN
1553-7404
Publication Date
March 2016
Volume
12
Issue
3
Start / End Page
e1005948
Location
United States
Related Subject Headings
- Signal Transduction
- Neurons
- Nervous System
- Nerve Growth Factors
- Gene Expression Regulation
- Gap Junctions
- Developmental Biology
- Caenorhabditis elegans Proteins
- Caenorhabditis elegans
- Axons
Citation
APA
Chicago
ICMJE
MLA
NLM
Meng, L., Chen, C.-H., & Yan, D. (2016). Regulation of Gap Junction Dynamics by UNC-44/ankyrin and UNC-33/CRMP through VAB-8 in C. elegans Neurons. PLoS Genet, 12(3), e1005948. https://doi.org/10.1371/journal.pgen.1005948
Meng, Lingfeng, Chia-hui Chen, and Dong Yan. “Regulation of Gap Junction Dynamics by UNC-44/ankyrin and UNC-33/CRMP through VAB-8 in C. elegans Neurons.” PLoS Genet 12, no. 3 (March 2016): e1005948. https://doi.org/10.1371/journal.pgen.1005948.
Meng L, Chen C-H, Yan D. Regulation of Gap Junction Dynamics by UNC-44/ankyrin and UNC-33/CRMP through VAB-8 in C. elegans Neurons. PLoS Genet. 2016 Mar;12(3):e1005948.
Meng, Lingfeng, et al. “Regulation of Gap Junction Dynamics by UNC-44/ankyrin and UNC-33/CRMP through VAB-8 in C. elegans Neurons.” PLoS Genet, vol. 12, no. 3, Mar. 2016, p. e1005948. Pubmed, doi:10.1371/journal.pgen.1005948.
Meng L, Chen C-H, Yan D. Regulation of Gap Junction Dynamics by UNC-44/ankyrin and UNC-33/CRMP through VAB-8 in C. elegans Neurons. PLoS Genet. 2016 Mar;12(3):e1005948.
Published In
PLoS Genet
DOI
EISSN
1553-7404
Publication Date
March 2016
Volume
12
Issue
3
Start / End Page
e1005948
Location
United States
Related Subject Headings
- Signal Transduction
- Neurons
- Nervous System
- Nerve Growth Factors
- Gene Expression Regulation
- Gap Junctions
- Developmental Biology
- Caenorhabditis elegans Proteins
- Caenorhabditis elegans
- Axons