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Unexpected positive control of NFκB and miR-155 by DGKα and ζ ensures effector and memory CD8+ T cell differentiation.

Publication ,  Journal Article
Yang, J; Zhang, P; Krishna, S; Wang, J; Lin, X; Huang, H; Xie, D; Gorentla, B; Huang, R; Gao, J; Li, Q-J; Zhong, X-P
Published in: Oncotarget
June 7, 2016

Signals from the T-cell receptor (TCR) and γ-chain cytokine receptors play crucial roles in initiating activation and effector/memory differentiation of CD8 T-cells. We report here that simultaneous deletion of both diacylglycerol kinase (DGK) α and ζ (DKO) severely impaired expansion of CD8 effector T cells and formation of memory CD8 T-cells after Listeria monocytogenes infection. Moreover, ablation of both DGKα and ζ in preformed memory CD8 T-cells triggered death and impaired homeostatic proliferation of these cells. DKO CD8 T-cells were impaired in priming due to decreased expression of chemokine receptors and migration to the draining lymph nodes. Moreover, DKO CD8 T-cells were unexpectedly defective in NFκB-mediated miR-155 transcript, leading to excessive SOCS1 expression and impaired γ-chain cytokine signaling. Our data identified a DGK-NFκB-miR-155-SOCS1 axis that bridges TCR and γ-chain cytokine signaling for robust CD8 T-cell primary and memory responses to bacterial infection.

Duke Scholars

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Published In

Oncotarget

DOI

EISSN

1949-2553

Publication Date

June 7, 2016

Volume

7

Issue

23

Start / End Page

33744 / 33764

Location

United States

Related Subject Headings

  • Signal Transduction
  • NF-kappa B
  • MicroRNAs
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Lymphocyte Activation
  • Listeriosis
  • Listeria monocytogenes
  • Immunologic Memory
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Yang, J., Zhang, P., Krishna, S., Wang, J., Lin, X., Huang, H., … Zhong, X.-P. (2016). Unexpected positive control of NFκB and miR-155 by DGKα and ζ ensures effector and memory CD8+ T cell differentiation. Oncotarget, 7(23), 33744–33764. https://doi.org/10.18632/oncotarget.8164
Yang, Jialong, Ping Zhang, Sruti Krishna, Jinli Wang, Xingguang Lin, Hongxiang Huang, Danli Xie, et al. “Unexpected positive control of NFκB and miR-155 by DGKα and ζ ensures effector and memory CD8+ T cell differentiation.Oncotarget 7, no. 23 (June 7, 2016): 33744–64. https://doi.org/10.18632/oncotarget.8164.
Yang J, Zhang P, Krishna S, Wang J, Lin X, Huang H, et al. Unexpected positive control of NFκB and miR-155 by DGKα and ζ ensures effector and memory CD8+ T cell differentiation. Oncotarget. 2016 Jun 7;7(23):33744–64.
Yang, Jialong, et al. “Unexpected positive control of NFκB and miR-155 by DGKα and ζ ensures effector and memory CD8+ T cell differentiation.Oncotarget, vol. 7, no. 23, June 2016, pp. 33744–64. Pubmed, doi:10.18632/oncotarget.8164.
Yang J, Zhang P, Krishna S, Wang J, Lin X, Huang H, Xie D, Gorentla B, Huang R, Gao J, Li Q-J, Zhong X-P. Unexpected positive control of NFκB and miR-155 by DGKα and ζ ensures effector and memory CD8+ T cell differentiation. Oncotarget. 2016 Jun 7;7(23):33744–33764.

Published In

Oncotarget

DOI

EISSN

1949-2553

Publication Date

June 7, 2016

Volume

7

Issue

23

Start / End Page

33744 / 33764

Location

United States

Related Subject Headings

  • Signal Transduction
  • NF-kappa B
  • MicroRNAs
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Lymphocyte Activation
  • Listeriosis
  • Listeria monocytogenes
  • Immunologic Memory