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Solid organ transplant donors with central nervous system infection.

Publication ,  Journal Article
Kaul, DR; Covington, S; Taranto, S; Green, M; Lyon, GM; Kusne, S; Miller, RA; Blumberg, EA
Published in: Transplantation
September 27, 2014

BACKGROUND: While donor-derived infections (DDI) remain uncommon, multiple reports describe DDI with pathogens that cause central nervous system (CNS) infection resulting in significant recipient disease. The Ad Hoc Disease Transmission Advisory Committee (DTAC) reviewed the records of potential donor-derived disease transmission events (PDDTE) to describe donor characteristics and outcomes associated with DDI from CNS pathogens. METHODS: All PDDTE reported from January 2008 to September 2010 were reviewed for characteristics suggesting CNS infection in the donor or the recipient. Identified cases were further examined to determine if donor CNS infection resulted in recipient infection. RESULTS: Ninety-one PDDTE cases in which there was concern for CNS infection in the donor or recipient were identified. Further review confirmed CNS infection in 12 donors, six of whom transmitted infection to 10 of 15 exposed recipients with five recipient deaths. Pathogens included Balamuthia mandrillaris, Cryptococcus neoformans, lymphocytic choriomeningitis virus, and West Nile virus. Listed cause of death at procurement for these donors included stroke, anoxia, acute disseminated encephalomyelitis, and meningoencephalitis. Confounding diagnoses were present in 6 of 12 donors that would have allowed them to be considered at low risk of transmitting a CNS pathogen. Of the six donors with no confounding conditions, three exhibited at least two suspicious "DTAC warning criteria" for CNS infection. CONCLUSION: Careful clinical assessment of donors combined with a high index of suspicion for ambiguous or misleading findings associated with CNS infection can reduce, but not eliminate, DDI with CNS pathogens.

Duke Scholars

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Published In

Transplantation

DOI

EISSN

1534-6080

Publication Date

September 27, 2014

Volume

98

Issue

6

Start / End Page

666 / 670

Location

United States

Related Subject Headings

  • West Nile virus
  • Tissue Donors
  • Surgery
  • Risk
  • Organ Transplantation
  • Middle Aged
  • Male
  • Lymphocytic choriomeningitis virus
  • Humans
  • Female
 

Citation

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Kaul, D. R., Covington, S., Taranto, S., Green, M., Lyon, G. M., Kusne, S., … Blumberg, E. A. (2014). Solid organ transplant donors with central nervous system infection. Transplantation, 98(6), 666–670. https://doi.org/10.1097/TP.0000000000000117
Kaul, Daniel R., Shandie Covington, Sarah Taranto, Michael Green, G Marshall Lyon, Shimon Kusne, Rachel A. Miller, and Emily A. Blumberg. “Solid organ transplant donors with central nervous system infection.Transplantation 98, no. 6 (September 27, 2014): 666–70. https://doi.org/10.1097/TP.0000000000000117.
Kaul DR, Covington S, Taranto S, Green M, Lyon GM, Kusne S, et al. Solid organ transplant donors with central nervous system infection. Transplantation. 2014 Sep 27;98(6):666–70.
Kaul, Daniel R., et al. “Solid organ transplant donors with central nervous system infection.Transplantation, vol. 98, no. 6, Sept. 2014, pp. 666–70. Pubmed, doi:10.1097/TP.0000000000000117.
Kaul DR, Covington S, Taranto S, Green M, Lyon GM, Kusne S, Miller RA, Blumberg EA. Solid organ transplant donors with central nervous system infection. Transplantation. 2014 Sep 27;98(6):666–670.

Published In

Transplantation

DOI

EISSN

1534-6080

Publication Date

September 27, 2014

Volume

98

Issue

6

Start / End Page

666 / 670

Location

United States

Related Subject Headings

  • West Nile virus
  • Tissue Donors
  • Surgery
  • Risk
  • Organ Transplantation
  • Middle Aged
  • Male
  • Lymphocytic choriomeningitis virus
  • Humans
  • Female