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The effect of hypercholesterolemia on early atherosclerotic lesions initiated by fibrinopeptide B.

Publication ,  Journal Article
Kadowaki, MH; Singh, TM; Zarins, CK; Glagov, S; Meredith, SC
Published in: J Surg Res
December 1991

Hypercholesterolemia and thrombosis have been implicated as factors in the development of atherosclerosis. Fibrinopeptide B (FPB) is a short chain peptide cleaved from fibrinogen during the production of fibrin. FPB is a known chemoattractant and has been shown to produce experimental atherosclerotic lesions in association with hypercholesterolemia. The present study was designed to examine the role of hypercholesterolemia in this process and to study the time course of the development of these lesions. Twelve New Zealand White rabbits were placed on an atherogenic diet and had suture carrying either FPB, fibrinopeptide A (FPA), or saline (controls) implanted in the adventitia of the femoral arteries and were sacrificed at 14 days. An equal number of animals were left on a standard diet and underwent similar treatment. Eleven animals were treated as the hypercholesterolemic group but were sacrificed at 2, 4, and 7 days. The thickness of the intima was measured adjacent to the suture in the animals sacrificed at 14 days, and the hypercholesterolemic FPB sites were thicker (12.23 mu +/- 6.60) than either hypercholesterolemic FPA (6.06 mu +/- 3.72), saline (4.94 mu +/- 1.42), or the normocholesterolemic FPB (5.99 mu +/- 4.61), FPA (3.89 mu +/- 2.20), or saline (3.97 mu +/- 1.83) (P less than 0.05 for all groups). Transmission electron microscopy of the hypercholesterolemic FPB group showed evidence of macrophages, actively secreting smooth muscle cells with newly deposited elastin, and foam cells by 7 days. We conclude that FPB attracts or stimulates macrophages and smooth muscle cells and that the resultant cellular and extracellular proliferation favors early atherosclerotic lesion formation in the presence of hypercholesterolemia.

Duke Scholars

Published In

J Surg Res

DOI

ISSN

0022-4804

Publication Date

December 1991

Volume

51

Issue

6

Start / End Page

524 / 528

Location

United States

Related Subject Headings

  • Sutures
  • Surgery
  • Rabbits
  • Microscopy, Electron
  • Hypercholesterolemia
  • Fibrinopeptide B
  • Fibrinopeptide A
  • Femoral Artery
  • Chromatography, High Pressure Liquid
  • Cholesterol
 

Citation

APA
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MLA
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Kadowaki, M. H., Singh, T. M., Zarins, C. K., Glagov, S., & Meredith, S. C. (1991). The effect of hypercholesterolemia on early atherosclerotic lesions initiated by fibrinopeptide B. J Surg Res, 51(6), 524–528. https://doi.org/10.1016/0022-4804(91)90176-m
Kadowaki, M. H., T. M. Singh, C. K. Zarins, S. Glagov, and S. C. Meredith. “The effect of hypercholesterolemia on early atherosclerotic lesions initiated by fibrinopeptide B.J Surg Res 51, no. 6 (December 1991): 524–28. https://doi.org/10.1016/0022-4804(91)90176-m.
Kadowaki MH, Singh TM, Zarins CK, Glagov S, Meredith SC. The effect of hypercholesterolemia on early atherosclerotic lesions initiated by fibrinopeptide B. J Surg Res. 1991 Dec;51(6):524–8.
Kadowaki, M. H., et al. “The effect of hypercholesterolemia on early atherosclerotic lesions initiated by fibrinopeptide B.J Surg Res, vol. 51, no. 6, Dec. 1991, pp. 524–28. Pubmed, doi:10.1016/0022-4804(91)90176-m.
Kadowaki MH, Singh TM, Zarins CK, Glagov S, Meredith SC. The effect of hypercholesterolemia on early atherosclerotic lesions initiated by fibrinopeptide B. J Surg Res. 1991 Dec;51(6):524–528.
Journal cover image

Published In

J Surg Res

DOI

ISSN

0022-4804

Publication Date

December 1991

Volume

51

Issue

6

Start / End Page

524 / 528

Location

United States

Related Subject Headings

  • Sutures
  • Surgery
  • Rabbits
  • Microscopy, Electron
  • Hypercholesterolemia
  • Fibrinopeptide B
  • Fibrinopeptide A
  • Femoral Artery
  • Chromatography, High Pressure Liquid
  • Cholesterol