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Comparative studies of prosthetic materials in the left atrium of the dog.

Publication ,  Journal Article
Kadowaki, MH; Levett, JM; Manjoney, DL; Wilson, CA; Glagov, S
Published in: Virchows Arch A Pathol Anat Histopathol
1987

To assess the healing process of various intracardiac prosthetic graft materials, we inserted autologous left atrium (control), autologous pericardium (AP), bovine pericardium (BP), polytetrafluoroethylene (PTEE) and woven Dacron (WD) patches into excised defects in the left atrial wall of 15 dogs. Two patches were implanted into each heart utilizing six patches for each material. Three months after graft placement, histological examination revealed chronic inflammation and fibrosis for all materials. Dense connective tissue surrounded the grafts in which fibrosis was most prominent. Cartilage formation occurred in 11 grafts: 5 BP, 4 PTFE, 1 control and 1 AP site. This change was not evident with WD. The extent of cartilage formation was greatest in BP. Bone formation occurred in 3 BP sites. 2 PTFE and 1 control site. Quantitative calcium concentrations were similar for all of the grafts without bone formation. Calcium concentrations at sites with bone formation averaged 15.13 mg/g +/- 6.39 mg/g compared to 0.939 +/- 0.419 for sites without bone formation (p less than 0.0001). We conclude that while inflammation, fibrosis and connective tissue thickening occur with healing of all graft materials, cartilage and bone formation differ with respect to the material employed.

Duke Scholars

Published In

Virchows Arch A Pathol Anat Histopathol

DOI

ISSN

0174-7398

Publication Date

1987

Volume

411

Issue

2

Start / End Page

173 / 177

Location

Germany

Related Subject Headings

  • Prostheses and Implants
  • Polytetrafluoroethylene
  • Polyethylene Terephthalates
  • Pericardium
  • Osteogenesis
  • Myocardium
  • Heart Atria
  • Fibrosis
  • Dogs
  • Cattle
 

Citation

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Chicago
ICMJE
MLA
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Kadowaki, M. H., Levett, J. M., Manjoney, D. L., Wilson, C. A., & Glagov, S. (1987). Comparative studies of prosthetic materials in the left atrium of the dog. Virchows Arch A Pathol Anat Histopathol, 411(2), 173–177. https://doi.org/10.1007/BF00712741
Kadowaki, M. H., J. M. Levett, D. L. Manjoney, C. A. Wilson, and S. Glagov. “Comparative studies of prosthetic materials in the left atrium of the dog.Virchows Arch A Pathol Anat Histopathol 411, no. 2 (1987): 173–77. https://doi.org/10.1007/BF00712741.
Kadowaki MH, Levett JM, Manjoney DL, Wilson CA, Glagov S. Comparative studies of prosthetic materials in the left atrium of the dog. Virchows Arch A Pathol Anat Histopathol. 1987;411(2):173–7.
Kadowaki, M. H., et al. “Comparative studies of prosthetic materials in the left atrium of the dog.Virchows Arch A Pathol Anat Histopathol, vol. 411, no. 2, 1987, pp. 173–77. Pubmed, doi:10.1007/BF00712741.
Kadowaki MH, Levett JM, Manjoney DL, Wilson CA, Glagov S. Comparative studies of prosthetic materials in the left atrium of the dog. Virchows Arch A Pathol Anat Histopathol. 1987;411(2):173–177.

Published In

Virchows Arch A Pathol Anat Histopathol

DOI

ISSN

0174-7398

Publication Date

1987

Volume

411

Issue

2

Start / End Page

173 / 177

Location

Germany

Related Subject Headings

  • Prostheses and Implants
  • Polytetrafluoroethylene
  • Polyethylene Terephthalates
  • Pericardium
  • Osteogenesis
  • Myocardium
  • Heart Atria
  • Fibrosis
  • Dogs
  • Cattle