Topography, cell response, and nerve regeneration.
In the body, cells encounter a complex milieu of signals, including topographical cues, in the form of the physical features of their surrounding environment. Imposed topography can affect cells on surfaces by promoting adhesion, spreading, alignment, morphological changes, and changes in gene expression. Neural response to topography is complex, and it depends on the dimensions and shapes of physical features. Looking toward repair of nerve injuries, strategies are being explored to engineer guidance conduits with precise surface topographies. How neurons and other cell types sense and interpret topography remains to be fully elucidated. Studies reviewed here include those of topography on cellular organization and function as well as potential cellular mechanisms of response.
Duke Scholars
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Related Subject Headings
- Neurons
- Nerve Regeneration
- Models, Animal
- Growth Cones
- Coated Materials, Biocompatible
- Biomedical Engineering
- Axons
- Animals
- 0903 Biomedical Engineering
Citation
Published In
DOI
EISSN
ISSN
Publication Date
Volume
Start / End Page
Related Subject Headings
- Neurons
- Nerve Regeneration
- Models, Animal
- Growth Cones
- Coated Materials, Biocompatible
- Biomedical Engineering
- Axons
- Animals
- 0903 Biomedical Engineering