Nanoparticles with targeting, triggered release, and imaging functionality for cancer applications
Publication
, Journal Article
Loomis, K; McNeeley, K; Bellamkonda, RV
Published in: Soft Matter
February 7, 2011
The tendency for nanoparticles to accumulate in tumor regions as a result of the enhanced permeability and retention effect has proven to be an advantageous feature for delivery of anti-cancer therapeutics and contrast agents for cancer detection. However, efficient drug delivery is dependent on nanoparticle stability in the circulation, accumulation and penetration into tumor tissues, and release of drugs to their sites of activity. Nanoparticles can be engineered bearing multiple functionalities to achieve optimal therapeutic and diagnostic effects. This review examines functionalities engineered into nanoparticles, including active targeting, triggered release of contents, and imaging capabilities. © 2011 The Royal Society of Chemistry.
Duke Scholars
Published In
Soft Matter
DOI
EISSN
1744-6848
ISSN
1744-683X
Publication Date
February 7, 2011
Volume
7
Issue
3
Start / End Page
839 / 856
Related Subject Headings
- Chemical Physics
- 51 Physical sciences
- 40 Engineering
- 34 Chemical sciences
- 09 Engineering
- 03 Chemical Sciences
- 02 Physical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Loomis, K., McNeeley, K., & Bellamkonda, R. V. (2011). Nanoparticles with targeting, triggered release, and imaging functionality for cancer applications. Soft Matter, 7(3), 839–856. https://doi.org/10.1039/c0sm00534g
Loomis, K., K. McNeeley, and R. V. Bellamkonda. “Nanoparticles with targeting, triggered release, and imaging functionality for cancer applications.” Soft Matter 7, no. 3 (February 7, 2011): 839–56. https://doi.org/10.1039/c0sm00534g.
Loomis K, McNeeley K, Bellamkonda RV. Nanoparticles with targeting, triggered release, and imaging functionality for cancer applications. Soft Matter. 2011 Feb 7;7(3):839–56.
Loomis, K., et al. “Nanoparticles with targeting, triggered release, and imaging functionality for cancer applications.” Soft Matter, vol. 7, no. 3, Feb. 2011, pp. 839–56. Scopus, doi:10.1039/c0sm00534g.
Loomis K, McNeeley K, Bellamkonda RV. Nanoparticles with targeting, triggered release, and imaging functionality for cancer applications. Soft Matter. 2011 Feb 7;7(3):839–856.
Published In
Soft Matter
DOI
EISSN
1744-6848
ISSN
1744-683X
Publication Date
February 7, 2011
Volume
7
Issue
3
Start / End Page
839 / 856
Related Subject Headings
- Chemical Physics
- 51 Physical sciences
- 40 Engineering
- 34 Chemical sciences
- 09 Engineering
- 03 Chemical Sciences
- 02 Physical Sciences