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Perceptibility and the "Choice Experience": User Sensory Perceptions and Experiences Inform Vaginal Prevention Product Design.

Publication ,  Journal Article
Guthrie, KM; Dunsiger, S; Vargas, SE; Fava, JL; Shaw, JG; Rosen, RK; Kiser, PF; Kojic, EM; Friend, DR; Katz, DF
Published in: AIDS research and human retroviruses
October 2016

The development of pericoital (on demand) vaginal HIV prevention technologies remains a global health priority. Clinical trials to date have been challenged by nonadherence, leading to an inability to demonstrate product efficacy. The work here provides new methodology and results to begin to address this limitation. We created validated scales that allow users to characterize sensory perceptions and experiences when using vaginal gel formulations. In this study, we sought to understand the user sensory perceptions and experiences (USPEs) that characterize the preferred product experience for each participant. Two hundred four women evaluated four semisolid vaginal formulations using the USPE scales at four randomly ordered formulation evaluation visits. Women were asked to select their preferred formulation experience for HIV prevention among the four formulations evaluated. The scale scores on the Sex-associated USPE scales (e.g., Initial Penetration and Leakage) for each participant's selected formulation were used in a latent class model analysis. Four classes of preferred formulation experiences were identified. Sociodemographic and sexual history variables did not predict class membership; however, four specific scales were significantly related to class: Initial Penetration, Perceived Wetness, Messiness, and Leakage. The range of preferred user experiences represented by the scale scores creates a potential target range for product development, such that products that elicit scale scores that fall within the preferred range may be more acceptable, or tolerable, to the population under study. It is recommended that similar analyses should be conducted with other semisolid vaginal formulations, and in other cultures, to determine product property and development targets.

Duke Scholars

Published In

AIDS research and human retroviruses

DOI

EISSN

1931-8405

ISSN

0889-2229

Publication Date

October 2016

Volume

32

Issue

10-11

Start / End Page

1022 / 1030

Related Subject Headings

  • Young Adult
  • Volunteers
  • Virology
  • Vaginal Creams, Foams, and Jellies
  • Pre-Exposure Prophylaxis
  • Patient Acceptance of Health Care
  • Middle Aged
  • Humans
  • HIV Infections
  • Female
 

Citation

APA
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ICMJE
MLA
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Guthrie, K. M., Dunsiger, S., Vargas, S. E., Fava, J. L., Shaw, J. G., Rosen, R. K., … Katz, D. F. (2016). Perceptibility and the "Choice Experience": User Sensory Perceptions and Experiences Inform Vaginal Prevention Product Design. AIDS Research and Human Retroviruses, 32(10–11), 1022–1030. https://doi.org/10.1089/aid.2015.0275
Guthrie, Kate Morrow, Shira Dunsiger, Sara E. Vargas, Joseph L. Fava, Julia G. Shaw, Rochelle K. Rosen, Patrick F. Kiser, E Milu Kojic, David R. Friend, and David F. Katz. “Perceptibility and the "Choice Experience": User Sensory Perceptions and Experiences Inform Vaginal Prevention Product Design.AIDS Research and Human Retroviruses 32, no. 10–11 (October 2016): 1022–30. https://doi.org/10.1089/aid.2015.0275.
Guthrie KM, Dunsiger S, Vargas SE, Fava JL, Shaw JG, Rosen RK, et al. Perceptibility and the "Choice Experience": User Sensory Perceptions and Experiences Inform Vaginal Prevention Product Design. AIDS research and human retroviruses. 2016 Oct;32(10–11):1022–30.
Guthrie, Kate Morrow, et al. “Perceptibility and the "Choice Experience": User Sensory Perceptions and Experiences Inform Vaginal Prevention Product Design.AIDS Research and Human Retroviruses, vol. 32, no. 10–11, Oct. 2016, pp. 1022–30. Epmc, doi:10.1089/aid.2015.0275.
Guthrie KM, Dunsiger S, Vargas SE, Fava JL, Shaw JG, Rosen RK, Kiser PF, Kojic EM, Friend DR, Katz DF. Perceptibility and the "Choice Experience": User Sensory Perceptions and Experiences Inform Vaginal Prevention Product Design. AIDS research and human retroviruses. 2016 Oct;32(10–11):1022–1030.
Journal cover image

Published In

AIDS research and human retroviruses

DOI

EISSN

1931-8405

ISSN

0889-2229

Publication Date

October 2016

Volume

32

Issue

10-11

Start / End Page

1022 / 1030

Related Subject Headings

  • Young Adult
  • Volunteers
  • Virology
  • Vaginal Creams, Foams, and Jellies
  • Pre-Exposure Prophylaxis
  • Patient Acceptance of Health Care
  • Middle Aged
  • Humans
  • HIV Infections
  • Female