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Protection against SHIV Challenge by Subcutaneous Administration of the Plant-Derived PGT121 Broadly Neutralizing Antibody in Macaques.

Publication ,  Journal Article
Rosenberg, YJ; Montefiori, DC; LaBranche, CC; Lewis, MG; Sack, M; Lees, JP; Jiang, X
Published in: PLoS One
2016
Published version (DOI) Link to item

Intravascular delivery of broadly neutralizing antibodies (bnAbs) has shown promise for prevention and treatment of HIV infection. However, multiple IV administrations in geographic locations with poor accessibility to medical care have practical limitations. We have assessed the efficacy of plant-derived PGT121 delivered subcutaneously (SC) against pre-and post-intravaginal challenge using a rigorous SHIV-SF162P3 macaque protection model. SC administered PGT121 exhibited a longer serum half-life than IV administration and was more consistent than intramuscular delivery. A dose of 3.5mg/kg PGT121 prevented infection at a minimum ID50 neutralization titer of 1:295 while 5mg/kg protected five of six macaques when delivered immediately post-challenge. These results suggest the utility of plant-derived bnAbs delivered SC for HIV prevention.

Duke Scholars

David Charles Montefiori
Author David Charles Montefiori Surgery, Surgical Sciences
Celia Crane LaBranche
Author Celia Crane LaBranche Surgery, Surgical Sciences
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Published In

PLoS One

DOI

10.1371/journal.pone.0152760

EISSN

1932-6203

Publication Date

2016

Volume

11

Issue

3

Start / End Page

e0152760

Location

United States

Related Subject Headings

  • Macaca mulatta
  • HIV-1
  • HIV Infections
  • HIV Antibodies
  • General Science & Technology
  • Female
  • Chlorocebus aethiops
  • Antibodies, Neutralizing
  • Animals
 

Citation

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Rosenberg, Y. J., Montefiori, D. C., LaBranche, C. C., Lewis, M. G., Sack, M., Lees, J. P., & Jiang, X. (2016). Protection against SHIV Challenge by Subcutaneous Administration of the Plant-Derived PGT121 Broadly Neutralizing Antibody in Macaques. PLoS One, 11(3), e0152760. https://doi.org/10.1371/journal.pone.0152760
Rosenberg, Yvonne J., David C. Montefiori, Celia C. LaBranche, Mark G. Lewis, Markus Sack, Jonathan P. Lees, and Xiaoming Jiang. “Protection against SHIV Challenge by Subcutaneous Administration of the Plant-Derived PGT121 Broadly Neutralizing Antibody in Macaques.” PLoS One 11, no. 3 (2016): e0152760. https://doi.org/10.1371/journal.pone.0152760.
Rosenberg YJ, Montefiori DC, LaBranche CC, Lewis MG, Sack M, Lees JP, et al. Protection against SHIV Challenge by Subcutaneous Administration of the Plant-Derived PGT121 Broadly Neutralizing Antibody in Macaques. PLoS One. 2016;11(3):e0152760.
Rosenberg, Yvonne J., et al. “Protection against SHIV Challenge by Subcutaneous Administration of the Plant-Derived PGT121 Broadly Neutralizing Antibody in Macaques.” PLoS One, vol. 11, no. 3, 2016, p. e0152760. Pubmed, doi:10.1371/journal.pone.0152760.
Rosenberg YJ, Montefiori DC, LaBranche CC, Lewis MG, Sack M, Lees JP, Jiang X. Protection against SHIV Challenge by Subcutaneous Administration of the Plant-Derived PGT121 Broadly Neutralizing Antibody in Macaques. PLoS One. 2016;11(3):e0152760.

Published In

PLoS One

DOI

10.1371/journal.pone.0152760

EISSN

1932-6203

Publication Date

2016

Volume

11

Issue

3

Start / End Page

e0152760

Location

United States

Related Subject Headings

  • Macaca mulatta
  • HIV-1
  • HIV Infections
  • HIV Antibodies
  • General Science & Technology
  • Female
  • Chlorocebus aethiops
  • Antibodies, Neutralizing
  • Animals