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Apolipoprotein A-IV interacts synergistically with melanocortins to reduce food intake.

Publication ,  Journal Article
Gotoh, K; Liu, M; Benoit, SC; Clegg, DJ; Davidson, WS; D'Alessio, D; Seeley, RJ; Tso, P; Woods, SC
Published in: Am J Physiol Regul Integr Comp Physiol
January 2006

Apolipoprotein (apo) A-IV is an anorexigenic gastrointestinal peptide that is also synthesized in the hypothalamus. The goal of these experiments was to determine whether apo A-IV interacts with the central melanocortin (MC) system in the control of feeding. The third ventricular (i3vt) administration of a subthreshold dose of apo A-IV (0.5 microg) potentiated i3vt MC-induced (metallothionein-II, 0.03 nmol) suppression of 30-min feeding in Long-Evans rats. A subthreshold dose of the MC antagonist (SHU9119, 0.1 nmol, i3vt) completely attenuated the anorectic effect of i3vt apo A-IV (1.5 microg). The i3vt apo A-IV significantly elevated the expression of c-Fos in neurons of the paraventricular nucleus of the hypothalamus, but not in the arcuate nucleus or median eminence. In addition, c-Fos expression was not colocalized with proopiomelanocortin-positive neurons. These data support a synergistic interaction between apo A-IV and melanocortins that reduces food intake by acting downstream of the arcuate.

Duke Scholars

Published In

Am J Physiol Regul Integr Comp Physiol

DOI

ISSN

0363-6119

Publication Date

January 2006

Volume

290

Issue

1

Start / End Page

R202 / R207

Location

United States

Related Subject Headings

  • Rats, Long-Evans
  • Rats
  • Pro-Opiomelanocortin
  • Physiology
  • Neurons
  • Metallothionein
  • Melanocyte-Stimulating Hormones
  • Male
  • Hypothalamus
  • Genes, fos
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Gotoh, K., Liu, M., Benoit, S. C., Clegg, D. J., Davidson, W. S., D’Alessio, D., … Woods, S. C. (2006). Apolipoprotein A-IV interacts synergistically with melanocortins to reduce food intake. Am J Physiol Regul Integr Comp Physiol, 290(1), R202–R207. https://doi.org/10.1152/ajpregu.00502.2005
Gotoh, Koro, Min Liu, Stephen C. Benoit, Deborah J. Clegg, W Sean Davidson, David D’Alessio, Randy J. Seeley, Patrick Tso, and Stephen C. Woods. “Apolipoprotein A-IV interacts synergistically with melanocortins to reduce food intake.Am J Physiol Regul Integr Comp Physiol 290, no. 1 (January 2006): R202–7. https://doi.org/10.1152/ajpregu.00502.2005.
Gotoh K, Liu M, Benoit SC, Clegg DJ, Davidson WS, D’Alessio D, et al. Apolipoprotein A-IV interacts synergistically with melanocortins to reduce food intake. Am J Physiol Regul Integr Comp Physiol. 2006 Jan;290(1):R202–7.
Gotoh, Koro, et al. “Apolipoprotein A-IV interacts synergistically with melanocortins to reduce food intake.Am J Physiol Regul Integr Comp Physiol, vol. 290, no. 1, Jan. 2006, pp. R202–07. Pubmed, doi:10.1152/ajpregu.00502.2005.
Gotoh K, Liu M, Benoit SC, Clegg DJ, Davidson WS, D’Alessio D, Seeley RJ, Tso P, Woods SC. Apolipoprotein A-IV interacts synergistically with melanocortins to reduce food intake. Am J Physiol Regul Integr Comp Physiol. 2006 Jan;290(1):R202–R207.

Published In

Am J Physiol Regul Integr Comp Physiol

DOI

ISSN

0363-6119

Publication Date

January 2006

Volume

290

Issue

1

Start / End Page

R202 / R207

Location

United States

Related Subject Headings

  • Rats, Long-Evans
  • Rats
  • Pro-Opiomelanocortin
  • Physiology
  • Neurons
  • Metallothionein
  • Melanocyte-Stimulating Hormones
  • Male
  • Hypothalamus
  • Genes, fos